Testing mitochondrial metabolic competence by cytochrome oxidase preferential cytochemistry versus immunoreactivity of subunits I and IV

Patrizia Fattoretti, Marta Balietti, Belinda Giorgetti, Yessica Grossi, Tiziana Casoli, Giuseppina Di Stefano, Carlo Bertoni-Freddari

Research output: Contribution to journalArticlepeer-review

Abstract

Cytochemically evidenced COX activity was compared with levels of immunohistochemically stained mitochondrial- and nuclear-encoded subunits (CO I and CO IV) in the dentate gyrus outer molecular layer (OML) and cerebellar granular layer (GL) of adult and old rats. COX activity decreased significantly in aging, whereas CO I and CO IV levels were significantly increased both in GL and OML of old animals. These findings suggest that the age-related decay of the mitochondrial metabolic competence is not caused by a reduction of COX subunits levels, but causal events affecting mitochondria as discrete morphofunctional units of the cellular bioenergetic machinery.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalRejuvenation Research
Volume9
Issue number2
DOIs
Publication statusPublished - Jun 2006

ASJC Scopus subject areas

  • Ageing

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