Testing models for genetic determination in migraine

M. Mochi, S. Sangiorgi, P. Cortelli, V. Carelli, C. Scapoli, M. Crisci, L. Monari, G. Pierangeli, P. Montagna

Research output: Contribution to journalArticlepeer-review


We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
Issue number6
Publication statusPublished - 1993


  • genetics of migraine
  • heritability
  • multiloci model
  • segregation analysis

ASJC Scopus subject areas

  • Clinical Neurology


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