Testing models for genetic determination in migraine

M. Mochi, S. Sangiorgi, P. Cortelli, V. Carelli, C. Scapoli, M. Crisci, L. Monari, G. Pierangeli, P. Montagna

Research output: Contribution to journalArticle

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Abstract

We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalCephalalgia
Volume13
Issue number6
DOIs
Publication statusPublished - 1993

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Migraine without Aura
Migraine with Aura
Penetrance
Genetic Models
Genetic Testing
Pedigree
Migraine Disorders
Mothers

Keywords

  • genetics of migraine
  • heritability
  • multiloci model
  • segregation analysis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Testing models for genetic determination in migraine. / Mochi, M.; Sangiorgi, S.; Cortelli, P.; Carelli, V.; Scapoli, C.; Crisci, M.; Monari, L.; Pierangeli, G.; Montagna, P.

In: Cephalalgia, Vol. 13, No. 6, 1993, p. 389-394.

Research output: Contribution to journalArticle

Mochi, M. ; Sangiorgi, S. ; Cortelli, P. ; Carelli, V. ; Scapoli, C. ; Crisci, M. ; Monari, L. ; Pierangeli, G. ; Montagna, P. / Testing models for genetic determination in migraine. In: Cephalalgia. 1993 ; Vol. 13, No. 6. pp. 389-394.
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