Testing models for genetic determination in migraine

M. Mochi, S. Sangiorgi, P. Cortelli, V. Carelli, C. Scapoli, M. Crisci, L. Monari, G. Pierangeli, P. Montagna

Research output: Contribution to journalArticlepeer-review

Abstract

We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalCephalalgia
Volume13
Issue number6
DOIs
Publication statusPublished - 1993

Keywords

  • genetics of migraine
  • heritability
  • multiloci model
  • segregation analysis

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Testing models for genetic determination in migraine'. Together they form a unique fingerprint.

Cite this