Testing Na+ in blood

Sebastiano A.G. Lava, Mario G. Bianchetti, Gregorio P. Milani

Research output: Contribution to journalComment/debatepeer-review


Both direct potentiometry and indirect potentiometry are currently used for Na+ testing in blood. These measurement techniques show good agreement as long as protein and lipid concentrations in blood remain normal. In severely ill patients, indirect potentiometry commonly leads to relevant errors in Na+ estimation: 25% of specimens show a disagreement between direct and indirect potentiometry, which is ≥4 mmol/L (mostly spuriously elevated Na+ level due to low circulating albumin concentration). There is a need for increased awareness of the poor performance of indirect potentiometry in some clinical settings.

Original languageEnglish
Pages (from-to)147-148
Number of pages2
JournalClinical Kidney Journal
Issue number2
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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