Testing the involvement of baroreflex during general anesthesia through Granger causality approach

Tito Bassani, Valentina Magagnin, Stefano Guzzetti, Giuseppe Baselli, Giuseppe Citerio, Alberto Porta

Research output: Contribution to journalArticlepeer-review

Abstract

Baroreflex sensitivity (BRS) is commonly assessed from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) during general anesthesia. Unfortunately, general anesthesia depresses autonomic function and, consequently, spontaneous SAP variations could not be capable to drive HP changes, thus preventing the use of spontaneous variability to infer BRS. We applied two Granger causality approaches (F-test and Wald test) during two anesthesiological strategies (i.e. sevoflurane plus remifentanil or propofol plus remifentanil). We found a significant Granger-causality from SAP to HP independently of the anesthesiological strategy; thus suggesting that techniques estimating BRS from spontaneous variability can be utilized during general anesthesia.

Original languageEnglish
Pages (from-to)306-312
Number of pages7
JournalComputers in Biology and Medicine
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Autonomic nervous system
  • Baroreflex
  • Cardiovascular control
  • General anesthesia
  • Granger causality

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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