Abstract
The main guidelines for cardiovascular disease prevention suggest that nutraceuticals could be an efficacious tool to improve lipid pattern. Our aim was to carry out a clinical trial comparing the metabolic effects of a combined nutraceutical containing both red yeast rice and polyunsaturated fatty acids (PUFAs) and a phytosterol-based approach in a setting of clinical practice. This was a multicenter open study with parallel control. We consecutively enrolled 107 pharmacologically untreated subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome, assigned to 8-week treatment with a combined treatment with red yeast rice (Dif1Stat®, including 5mg monacolin K) and 610mg PUFAs. A parallel group of 30 subjects with similar characteristics was treated with phytosterols 1600mg/die. In the combined nutraceutical group, compared with the baseline level, we observed a significant decrease in total cholesterol (TC; -42.50±18.1mg/dL), low-density lipoprotein cholesterol (LDL-C; -37.6±13.6mg/dL), triglycerides (TG; -19.8±25.1mg/dL), and non-HDL-C (-43.1±17.7mg/dL) (all P
| Original language | English |
|---|---|
| Pages (from-to) | 1270-1273 |
| Number of pages | 4 |
| Journal | Journal of Medicinal Food |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2015 |
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Keywords
- Dietary supplements
- Hypercholesterolemia
- Monacolins
- Nutraceuticals
- Phytosterols
- PUFA
- Red yeast rice
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Testing the Short-Term Efficacy of a Lipid-Lowering Nutraceutical in the Setting of Clinical Practice : A Multicenter Study. / Cicero, Arrigo F G; Derosa, Giuseppe; Pisciotta, Livia; Barbagallo, Carlo.
In: Journal of Medicinal Food, Vol. 18, No. 11, 01.11.2015, p. 1270-1273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Testing the Short-Term Efficacy of a Lipid-Lowering Nutraceutical in the Setting of Clinical Practice
T2 - A Multicenter Study
AU - Cicero, Arrigo F G
AU - Derosa, Giuseppe
AU - Pisciotta, Livia
AU - Barbagallo, Carlo
PY - 2015/11/1
Y1 - 2015/11/1
N2 - The main guidelines for cardiovascular disease prevention suggest that nutraceuticals could be an efficacious tool to improve lipid pattern. Our aim was to carry out a clinical trial comparing the metabolic effects of a combined nutraceutical containing both red yeast rice and polyunsaturated fatty acids (PUFAs) and a phytosterol-based approach in a setting of clinical practice. This was a multicenter open study with parallel control. We consecutively enrolled 107 pharmacologically untreated subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome, assigned to 8-week treatment with a combined treatment with red yeast rice (Dif1Stat®, including 5mg monacolin K) and 610mg PUFAs. A parallel group of 30 subjects with similar characteristics was treated with phytosterols 1600mg/die. In the combined nutraceutical group, compared with the baseline level, we observed a significant decrease in total cholesterol (TC; -42.50±18.1mg/dL), low-density lipoprotein cholesterol (LDL-C; -37.6±13.6mg/dL), triglycerides (TG; -19.8±25.1mg/dL), and non-HDL-C (-43.1±17.7mg/dL) (all P
AB - The main guidelines for cardiovascular disease prevention suggest that nutraceuticals could be an efficacious tool to improve lipid pattern. Our aim was to carry out a clinical trial comparing the metabolic effects of a combined nutraceutical containing both red yeast rice and polyunsaturated fatty acids (PUFAs) and a phytosterol-based approach in a setting of clinical practice. This was a multicenter open study with parallel control. We consecutively enrolled 107 pharmacologically untreated subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome, assigned to 8-week treatment with a combined treatment with red yeast rice (Dif1Stat®, including 5mg monacolin K) and 610mg PUFAs. A parallel group of 30 subjects with similar characteristics was treated with phytosterols 1600mg/die. In the combined nutraceutical group, compared with the baseline level, we observed a significant decrease in total cholesterol (TC; -42.50±18.1mg/dL), low-density lipoprotein cholesterol (LDL-C; -37.6±13.6mg/dL), triglycerides (TG; -19.8±25.1mg/dL), and non-HDL-C (-43.1±17.7mg/dL) (all P
KW - Dietary supplements
KW - Hypercholesterolemia
KW - Monacolins
KW - Nutraceuticals
KW - Phytosterols
KW - PUFA
KW - Red yeast rice
UR - http://www.scopus.com/inward/record.url?scp=84946014500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946014500&partnerID=8YFLogxK
U2 - 10.1089/jmf.2015.0024
DO - 10.1089/jmf.2015.0024
M3 - Article
AN - SCOPUS:84946014500
VL - 18
SP - 1270
EP - 1273
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
SN - 1096-620X
IS - 11
ER -