Abstract
The main guidelines for cardiovascular disease prevention suggest that nutraceuticals could be an efficacious tool to improve lipid pattern. Our aim was to carry out a clinical trial comparing the metabolic effects of a combined nutraceutical containing both red yeast rice and polyunsaturated fatty acids (PUFAs) and a phytosterol-based approach in a setting of clinical practice. This was a multicenter open study with parallel control. We consecutively enrolled 107 pharmacologically untreated subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome, assigned to 8-week treatment with a combined treatment with red yeast rice (Dif1Stat®, including 5mg monacolin K) and 610mg PUFAs. A parallel group of 30 subjects with similar characteristics was treated with phytosterols 1600mg/die. In the combined nutraceutical group, compared with the baseline level, we observed a significant decrease in total cholesterol (TC; -42.50±18.1mg/dL), low-density lipoprotein cholesterol (LDL-C; -37.6±13.6mg/dL), triglycerides (TG; -19.8±25.1mg/dL), and non-HDL-C (-43.1±17.7mg/dL) (all P
Original language | English |
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Pages (from-to) | 1270-1273 |
Number of pages | 4 |
Journal | Journal of Medicinal Food |
Volume | 18 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1 2015 |
Keywords
- Dietary supplements
- Hypercholesterolemia
- Monacolins
- Nutraceuticals
- Phytosterols
- PUFA
- Red yeast rice
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics