Testosterone and biological characteristics of breast cancers in postmenopausal women

Giorgio Secreto, Elisabetta Venturelli, Elisabetta Meneghini, Marco Greco, Cristina Ferraris, Massimo Gion, Matelda Zancan, Aline S C Fabricio, Franco Berrino, Adalberto Cavalleri, Andrea Micheli

Research output: Contribution to journalArticle

Abstract

Androgens are involved in the development of breast cancer, although the mechanisms remain unclear. To further investigate androgens in breast cancer, we examined the relations between serum testosterone and age, body mass index (BMI), tumor size, histologic type, grade, axillary node involvement, estrogen receptor status, progesterone receptor status, and HER2 overexpression in a cross-sectional study of 592 postmenopausal breast cancer patients. Mean testosterone differences according to categories of patient and tumor characteristics were assayed by Fisher's or Kruskall-Wallis test as appropriate; adjusted odds ratios (OR) of having a tumor characteristic by testosterone tertiles were estimated by logistic regression. Testosterone concentrations were significantly higher in women with BMI ≥30 versus BMI

Original languageEnglish
Pages (from-to)2942-2948
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2009

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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  • Cite this

    Secreto, G., Venturelli, E., Meneghini, E., Greco, M., Ferraris, C., Gion, M., Zancan, M., Fabricio, A. S. C., Berrino, F., Cavalleri, A., & Micheli, A. (2009). Testosterone and biological characteristics of breast cancers in postmenopausal women. Cancer Epidemiology Biomarkers and Prevention, 18(11), 2942-2948. https://doi.org/10.1158/1055-9965.EPI-09-0540