TY - JOUR
T1 - Testosterone and biological characteristics of breast cancers in postmenopausal women
AU - Secreto, Giorgio
AU - Venturelli, Elisabetta
AU - Meneghini, Elisabetta
AU - Greco, Marco
AU - Ferraris, Cristina
AU - Gion, Massimo
AU - Zancan, Matelda
AU - Fabricio, Aline S C
AU - Berrino, Franco
AU - Cavalleri, Adalberto
AU - Micheli, Andrea
PY - 2009/11
Y1 - 2009/11
N2 - Androgens are involved in the development of breast cancer, although the mechanisms remain unclear. To further investigate androgens in breast cancer, we examined the relations between serum testosterone and age, body mass index (BMI), tumor size, histologic type, grade, axillary node involvement, estrogen receptor status, progesterone receptor status, and HER2 overexpression in a cross-sectional study of 592 postmenopausal breast cancer patients. Mean testosterone differences according to categories of patient and tumor characteristics were assayed by Fisher's or Kruskall-Wallis test as appropriate; adjusted odds ratios (OR) of having a tumor characteristic by testosterone tertiles were estimated by logistic regression. Testosterone concentrations were significantly higher in women with BMI ≥30 versus BMI
AB - Androgens are involved in the development of breast cancer, although the mechanisms remain unclear. To further investigate androgens in breast cancer, we examined the relations between serum testosterone and age, body mass index (BMI), tumor size, histologic type, grade, axillary node involvement, estrogen receptor status, progesterone receptor status, and HER2 overexpression in a cross-sectional study of 592 postmenopausal breast cancer patients. Mean testosterone differences according to categories of patient and tumor characteristics were assayed by Fisher's or Kruskall-Wallis test as appropriate; adjusted odds ratios (OR) of having a tumor characteristic by testosterone tertiles were estimated by logistic regression. Testosterone concentrations were significantly higher in women with BMI ≥30 versus BMI
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U2 - 10.1158/1055-9965.EPI-09-0540
DO - 10.1158/1055-9965.EPI-09-0540
M3 - Article
C2 - 19843675
AN - SCOPUS:72749102007
VL - 18
SP - 2942
EP - 2948
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 11
ER -