Testosterone and sleep-related erections: An overview

Francesco Montorsi, Michael Oettel

Research output: Contribution to journalArticlepeer-review


Sleep-related erections have been reported to occur from the intrauterine life to senescence. It has been speculated that the main function of nocturnal erections is to provide adequate engorgement of the corpora cavernosa, which then leads to increased tissue oxygenation. This is in turn to prevent cavernous fibrosis, the histopathological basis for corporeal venoocclusive dysfunction, which probably is the most common cause of organic erectile dysfunction. It has been suggested that sleep-related erections are triggered by the release of nitric oxide by the nitrergic nerve fibers within the cavernous nerves. Androgens regulate this mechanism as well as some other non-nitrergic processes within the corpora cavernosa and within the central nervous system. By contrast, the erectile response to tactile or visual erotic stimuli in wakefulness predominantly involves an androgen-independent system, although it may, at least to a certain degree, also be influenced by androgen-sensitive mechanisms. No doubt, androgens are key players in the physiology of nocturnal erections, and the availability of new, user-friendly testosterone preparations such as transdermal gel and intramuscularly administered testosterone undecanoate stimulates further investigations on this field. The prospect that the quality of sleep may also be improved by an androgen therapy administered to improve sleep-related erections in hypogonadal men needs further basic research and appropriate clinical studies.

Original languageEnglish
Pages (from-to)771-784
Number of pages14
JournalJournal of Sexual Medicine
Issue number6
Publication statusPublished - Nov 2005


  • Androgens
  • Erectile Dysfunction
  • Penile Tumescence
  • Sleep-Related Erections
  • Testosterone

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Urology


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