Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

I. Roglio, R. Bianchi, S. Giatti, G. Cavaletti, D. Caruso, S. Scurati, D. Crippa, L. M. Garcia-Segura, F. Camozzi, G. Lauria, R. C. Melcangi

Research output: Contribution to journalArticle

Abstract

In this study we have assessed the effect of testosterone (T), dihydrotestosterone (DHT) and 5αandrostan-3α, 17β-diol (3α-diol) therapies on diabetic neuropathy. Diabetes was induced in adult male rats by the injection of streptozotocin and resulted in decreased T and increased 3α-diol levels in plasma and in decreased levels of pregnenolone and DHT in the sciatic nerve. Moreover, a reduced expression of the enzyme converting Tinto DHT (i.e., the 5α-reductase) also occurs at the level of sciatic nerve, suggesting that the decrease of DHT levels could be due to an impairment of this enzyme. Chronic treatment for 1 month with DHT or 3α-diol increased tail nerve conduction velocity and partially counteracted the increase of thermal threshold induced by diabetes. Treatment with DHT increased tibial Na+,K+-ATPase activity and the expression of myelin protein P0 in the sciatic nerve.DHT, 3α-diol and T reversed the reduction of intra-epidermal nerve fiber density induced by diabetes. These observations indicate that T metabolites can reverse behavioral, neurophysiological, morphological and biochemical alterations induced by peripheral diabetic neuropathy.

Original languageEnglish
Pages (from-to)1158-1168
Number of pages11
JournalCellular and Molecular Life Sciences
Volume64
Issue number9
DOIs
Publication statusPublished - May 2007

Fingerprint

Diabetic Neuropathies
Dihydrotestosterone
Neuroprotective Agents
Testosterone
Derivatives
Sciatic Nerve
Medical problems
Myelin P0 Protein
Pregnenolone
Neural Conduction
Peripheral Nervous System Diseases
Enzymes
Streptozocin
Metabolites
Nerve Fibers
Adenosine Triphosphatases
Tail
Rats
Oxidoreductases
Therapeutics

Keywords

  • 3α-diol
  • 5α-reductase
  • Androgen receptor
  • Dihydrotestosterone
  • Neuroactive steroids
  • Rat
  • Sciatic nerve
  • Streptozotocin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Roglio, I., Bianchi, R., Giatti, S., Cavaletti, G., Caruso, D., Scurati, S., ... Melcangi, R. C. (2007). Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy. Cellular and Molecular Life Sciences, 64(9), 1158-1168. https://doi.org/10.1007/s00018-007-7002-5

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy. / Roglio, I.; Bianchi, R.; Giatti, S.; Cavaletti, G.; Caruso, D.; Scurati, S.; Crippa, D.; Garcia-Segura, L. M.; Camozzi, F.; Lauria, G.; Melcangi, R. C.

In: Cellular and Molecular Life Sciences, Vol. 64, No. 9, 05.2007, p. 1158-1168.

Research output: Contribution to journalArticle

Roglio, I, Bianchi, R, Giatti, S, Cavaletti, G, Caruso, D, Scurati, S, Crippa, D, Garcia-Segura, LM, Camozzi, F, Lauria, G & Melcangi, RC 2007, 'Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy', Cellular and Molecular Life Sciences, vol. 64, no. 9, pp. 1158-1168. https://doi.org/10.1007/s00018-007-7002-5
Roglio, I. ; Bianchi, R. ; Giatti, S. ; Cavaletti, G. ; Caruso, D. ; Scurati, S. ; Crippa, D. ; Garcia-Segura, L. M. ; Camozzi, F. ; Lauria, G. ; Melcangi, R. C. / Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy. In: Cellular and Molecular Life Sciences. 2007 ; Vol. 64, No. 9. pp. 1158-1168.
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