Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts

A. Petroni; N. Papini; M. Blasevich; V. Magnaghi; I. Cavarretta; C. Galli; R. C. Melcangi

doi:10.1016/S0304-3940(00)01296-9

Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts

A. Petroni, N. Papini, M. Blasevich, V. Magnaghi, I. Cavarretta, C. Galli, R. C. Melcangi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	139-142
Number of pages	4
Journal	Neuroscience Letters
Volume	289
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(00)01296-9
Publication status	Published - Aug 4 2000

Keywords

3α-Diol
5α-Androstan-17β-ol-3-one
5α-Androstan-3α,17β-diol
Dihydrotestosterone
Testosterone
Very long chain fatty acids
X-adrenoleukodystrophy

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(00)01296-9

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title = "Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts",

abstract = "Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "3α-Diol, 5α-Androstan-17β-ol-3-one, 5α-Androstan-3α,17β-diol, Dihydrotestosterone, Testosterone, Very long chain fatty acids, X-adrenoleukodystrophy",

author = "A. Petroni and N. Papini and M. Blasevich and V. Magnaghi and I. Cavarretta and C. Galli and Melcangi, {R. C.}",

year = "2000",

month = aug,

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doi = "10.1016/S0304-3940(00)01296-9",

language = "English",

volume = "289",

pages = "139--142",

journal = "Neuroscience Letters",

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T1 - Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts

AU - Petroni, A.

AU - Papini, N.

AU - Blasevich, M.

AU - Magnaghi, V.

AU - Cavarretta, I.

AU - Galli, C.

AU - Melcangi, R. C.

PY - 2000/8/4

Y1 - 2000/8/4

N2 - Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - 3α-Diol

KW - 5α-Androstan-17β-ol-3-one

KW - 5α-Androstan-3α,17β-diol

KW - Dihydrotestosterone

KW - Testosterone

KW - Very long chain fatty acids

KW - X-adrenoleukodystrophy

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U2 - 10.1016/S0304-3940(00)01296-9

DO - 10.1016/S0304-3940(00)01296-9

M3 - Article

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AN - SCOPUS:0033934566

VL - 289

SP - 139

EP - 142

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -

Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts

Abstract

Keywords

ASJC Scopus subject areas

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