Abstract
Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 139-142 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 289 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 4 2000 |
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Keywords
- 3α-Diol
- 5α-Androstan-17β-ol-3-one
- 5α-Androstan-3α,17β-diol
- Dihydrotestosterone
- Testosterone
- Very long chain fatty acids
- X-adrenoleukodystrophy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. / Petroni, A.; Papini, N.; Blasevich, M.; Magnaghi, V.; Cavarretta, I.; Galli, C.; Melcangi, R. C.
In: Neuroscience Letters, Vol. 289, No. 2, 04.08.2000, p. 139-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts
AU - Petroni, A.
AU - Papini, N.
AU - Blasevich, M.
AU - Magnaghi, V.
AU - Cavarretta, I.
AU - Galli, C.
AU - Melcangi, R. C.
PY - 2000/8/4
Y1 - 2000/8/4
N2 - Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - 3α-Diol
KW - 5α-Androstan-17β-ol-3-one
KW - 5α-Androstan-3α,17β-diol
KW - Dihydrotestosterone
KW - Testosterone
KW - Very long chain fatty acids
KW - X-adrenoleukodystrophy
UR - http://www.scopus.com/inward/record.url?scp=0033934566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033934566&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(00)01296-9
DO - 10.1016/S0304-3940(00)01296-9
M3 - Article
C2 - 10904139
AN - SCOPUS:0033934566
VL - 289
SP - 139
EP - 142
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -