Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts

A. Petroni, N. Papini, M. Blasevich, V. Magnaghi, I. Cavarretta, C. Galli, R. C. Melcangi

Research output: Contribution to journalArticle

Abstract

Testosterone metabolites (dihydrotestosterone, DHT) and 5α-androstan-3α,17β-diol (3α-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3α-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalNeuroscience Letters
Volume289
Issue number2
DOIs
Publication statusPublished - Aug 4 2000

Keywords

  • 3α-Diol
  • 5α-Androstan-17β-ol-3-one
  • 5α-Androstan-3α,17β-diol
  • Dihydrotestosterone
  • Testosterone
  • Very long chain fatty acids
  • X-adrenoleukodystrophy

ASJC Scopus subject areas

  • Neuroscience(all)

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