TY - JOUR
T1 - Testosterone treatment in chronic heart failure. Review of literature and future perspectives
AU - D’Assante, Roberta
AU - Piccioli, Lucrezia
AU - Valente, Pietro
AU - Stagnaro, Francesca M.
AU - Schiavo, Alessandra
AU - Lombardi, Anna
AU - Panicara, Veronica
AU - Arcopinto, Michele
AU - Vitale, Giuseppe
AU - Sarullo, Filippo M.
AU - Giallauria, Francesco
AU - Marra, Alberto M.
AU - Salzano, Andrea
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Mounting evidence suggests that hormonal deficiencies (HD) have an important role in chronic heart failure (CHF). In particular, androgen depletion is common in men with CHF and is associated with increased morbidity and mortality. This review summarizes the current understanding of the complex relationship between CHF and testosterone, focusing on evidence derived from clinical trials that have investigated the role of testosterone in the treatment of CHF. A greater comprehension of this area will allow researchers and clinicians to plan future studies that improve current strategies to reduce mortality in this high-risk population. Online databases PubMed (Medline), Web of Science, and Scopus were searched for manuscripts published prior mme to June 2018 using key words “heart failure” AND “testosterone” OR “anabolism” OR “hormone” OR “replacement treatment”. Manuscripts were collated, studied and carried forward for discussion where appropriate. In summary, findings from the literature demonstrate that testosterone treatment in CHF is a promising topic that requires further investigation.
AB - Mounting evidence suggests that hormonal deficiencies (HD) have an important role in chronic heart failure (CHF). In particular, androgen depletion is common in men with CHF and is associated with increased morbidity and mortality. This review summarizes the current understanding of the complex relationship between CHF and testosterone, focusing on evidence derived from clinical trials that have investigated the role of testosterone in the treatment of CHF. A greater comprehension of this area will allow researchers and clinicians to plan future studies that improve current strategies to reduce mortality in this high-risk population. Online databases PubMed (Medline), Web of Science, and Scopus were searched for manuscripts published prior mme to June 2018 using key words “heart failure” AND “testosterone” OR “anabolism” OR “hormone” OR “replacement treatment”. Manuscripts were collated, studied and carried forward for discussion where appropriate. In summary, findings from the literature demonstrate that testosterone treatment in CHF is a promising topic that requires further investigation.
KW - Anabolism
KW - Cardiovascular disease
KW - Heart
KW - Heart failure
KW - Hormones
KW - Testosterone
UR - http://www.scopus.com/inward/record.url?scp=85052931766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052931766&partnerID=8YFLogxK
U2 - 10.4081/monaldi.2018.976
DO - 10.4081/monaldi.2018.976
M3 - Article
AN - SCOPUS:85052931766
VL - 88
SP - 10
EP - 14
JO - Monaldi Archives for Chest Disease
JF - Monaldi Archives for Chest Disease
SN - 1122-0643
IS - 3
ER -