Tests of Coagulation in Liver Disease

Research output: Contribution to journalArticle

Abstract

The complex coagulation defect secondary to chronic liver disease is considered responsible for the bleeding problems that often are associated with the disease. Accordingly, clinicians order laboratory tests to assess the risk of bleeding and rely on these results to make decisions about the management of the associated coagulation disturbances. Recent data, however, indicate that the abnormality of coagulation in stable cirrhosis is more a myth than a reality and may help explain why the prolonged global coagulation tests are poor predictors of bleeding in this setting. Alternative tests more closely mimicking what occurs in vivo should be developed and investigated in appropriate clinical trials to determine their value in the management of bleeding in cirrhosis.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalClinics in Liver Disease
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Activated partial thromboplastin time
  • Bleeding
  • Cirrhosis
  • Coagulation tests
  • Fibrinolysis
  • Prothrombin time
  • Thrombin generation
  • Thromboelastography

ASJC Scopus subject areas

  • Hepatology

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