Tether and trap: Regulation of membrane-raft dynamics by actin-binding proteins

Antonella Viola, Neetu Gupta

Research output: Contribution to journalArticlepeer-review


The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipid-based reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein-lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.

Original languageEnglish
Pages (from-to)889-896
Number of pages8
JournalNature Reviews Immunology
Issue number11
Publication statusPublished - Nov 2007

ASJC Scopus subject areas

  • Immunology


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