Tether and trap: Regulation of membrane-raft dynamics by actin-binding proteins

Antonella Viola, Neetu Gupta

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipid-based reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein-lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.

Original languageEnglish
Pages (from-to)889-896
Number of pages8
JournalNature Reviews Immunology
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Microfilament Proteins
Cell Membrane
Membranes
Lymphocyte Activation
Membrane Microdomains
Lipids
Actin Cytoskeleton
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Tether and trap : Regulation of membrane-raft dynamics by actin-binding proteins. / Viola, Antonella; Gupta, Neetu.

In: Nature Reviews Immunology, Vol. 7, No. 11, 11.2007, p. 889-896.

Research output: Contribution to journalArticle

Viola, Antonella ; Gupta, Neetu. / Tether and trap : Regulation of membrane-raft dynamics by actin-binding proteins. In: Nature Reviews Immunology. 2007 ; Vol. 7, No. 11. pp. 889-896.
@article{2708fb34f8904b50af9b2e06b5d2bcd1,
title = "Tether and trap: Regulation of membrane-raft dynamics by actin-binding proteins",
abstract = "The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipid-based reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein-lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.",
author = "Antonella Viola and Neetu Gupta",
year = "2007",
month = "11",
doi = "10.1038/nri2193",
language = "English",
volume = "7",
pages = "889--896",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Tether and trap

T2 - Regulation of membrane-raft dynamics by actin-binding proteins

AU - Viola, Antonella

AU - Gupta, Neetu

PY - 2007/11

Y1 - 2007/11

N2 - The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipid-based reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein-lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.

AB - The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipid-based reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein-lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.

UR - http://www.scopus.com/inward/record.url?scp=35548942611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35548942611&partnerID=8YFLogxK

U2 - 10.1038/nri2193

DO - 10.1038/nri2193

M3 - Article

C2 - 17948020

AN - SCOPUS:35548942611

VL - 7

SP - 889

EP - 896

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 11

ER -