Tetracyclines in COVID-19 patients quarantined at home: Literature evidence supporting real-world data from a multicenter observational study targeting inflammatory and infectious dermatoses

Laura Cristina Gironi, Giovanni Damiani, Elisa Zavattaro, Alessia Pacifico, Pierachille Santus, Paolo Daniele Maria Pigatto, Ottavio Cremona, Paola Savoia

Research output: Contribution to journalArticlepeer-review

Abstract

Tetracyclines (TetraC) are widely used in dermatology for both inflammatory and infectious dermatoses; recently both in vivo and in vitro studies started to suggest also a potential antiviral effect. During COVID-19 outbreak, several dermatological patients contracted SARS-CoV-2 experiencing only mild symptoms, but no protocol were approved. A multicenter prospective observational study that enrolled COVID-19 patients visited with teledermatology and undergoing TetraC was performed. About 38 adult outpatients (M/F: 20/18, age 42.6 years [21-67]) were enrolled. During the TetraC treatment, symptoms resolved in all patients within 10 days. Remarkably, ageusia and anosmia disappeared in the first week of TetraC treatment. TetraC seem a promising drug to treat COVID-19 outpatients with mild symptoms.

Original languageEnglish
JournalDermatologic Therapy
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • COVID-19
  • doxycycline
  • drug re-proposal
  • inflammatory dermatoses
  • minocycline
  • SARS-Cov-2
  • tetracyclines

ASJC Scopus subject areas

  • Dermatology

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