Tetrahydropapaveroline: Formation in vivo and in vitro in rat brain

Anthony J. Turner; Kenneth M. Baker; Sergio Algeri; Alberto Frigerio; Silvio Garattini

doi:10.1016/0024-3205(74)90106-4

Tetrahydropapaveroline: Formation in vivo and in vitro in rat brain

Anthony J. Turner, Kenneth M. Baker, Sergio Algeri, Alberto Frigerio, Silvio Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Gas chromatographic-mass spectrometric techniques have been used for the measurement of tetrahydropapaveroline (THP) from brain. The formation of THP from 1-DOPA or dopamine in vitro has been confirmed by obtaining a complete mass spectrum of the product as its trifluoroacetylated derivative. Following chronic administration of 1-DOPA or 1-DOPA in combination with ethanol to rats, THP formed in vivo in in brain could be detected in small quantities although it could not be detected when ethanol alone was administered.

Original language	English
Pages (from-to)	2247-2257
Number of pages	11
Journal	Life Sciences
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(74)90106-4
Publication status	Published - Jun 1 1974

ASJC Scopus subject areas

Pharmacology

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10.1016/0024-3205(74)90106-4

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abstract = "Gas chromatographic-mass spectrometric techniques have been used for the measurement of tetrahydropapaveroline (THP) from brain. The formation of THP from 1-DOPA or dopamine in vitro has been confirmed by obtaining a complete mass spectrum of the product as its trifluoroacetylated derivative. Following chronic administration of 1-DOPA or 1-DOPA in combination with ethanol to rats, THP formed in vivo in in brain could be detected in small quantities although it could not be detected when ethanol alone was administered.",

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AU - Frigerio, Alberto

AU - Garattini, Silvio

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Tetrahydropapaveroline: Formation in vivo and in vitro in rat brain

Abstract

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