Abstract
Gas chromatographic-mass spectrometric techniques have been used for the measurement of tetrahydropapaveroline (THP) from brain. The formation of THP from 1-DOPA or dopamine in vitro has been confirmed by obtaining a complete mass spectrum of the product as its trifluoroacetylated derivative. Following chronic administration of 1-DOPA or 1-DOPA in combination with ethanol to rats, THP formed in vivo in in brain could be detected in small quantities although it could not be detected when ethanol alone was administered.
Original language | English |
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Pages (from-to) | 2247-2257 |
Number of pages | 11 |
Journal | Life Sciences |
Volume | 14 |
Issue number | 11 |
DOIs | |
Publication status | Published - Jun 1 1974 |
ASJC Scopus subject areas
- Pharmacology