Tetrahydropapaveroline: Formation in vivo and in vitro in rat brain

Anthony J. Turner, Kenneth M. Baker, Sergio Algeri, Alberto Frigerio, Silvio Garattini

Research output: Contribution to journalArticlepeer-review


Gas chromatographic-mass spectrometric techniques have been used for the measurement of tetrahydropapaveroline (THP) from brain. The formation of THP from 1-DOPA or dopamine in vitro has been confirmed by obtaining a complete mass spectrum of the product as its trifluoroacetylated derivative. Following chronic administration of 1-DOPA or 1-DOPA in combination with ethanol to rats, THP formed in vivo in in brain could be detected in small quantities although it could not be detected when ethanol alone was administered.

Original languageEnglish
Pages (from-to)2247-2257
Number of pages11
JournalLife Sciences
Issue number11
Publication statusPublished - Jun 1 1974

ASJC Scopus subject areas

  • Pharmacology


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