Tetraploidy (92,XXYY) in an acute nonlymphocytic leukemia (M1) patient following autologous bone marrow transplantation

Leopoldo Zelante, Gianni Perla, Carlo Bodenizza, Mario M. Greco, Mario Carotenuto, Bruno Dallapiccola

Research output: Contribution to journalArticlepeer-review

Abstract

Tetraploidy (4n = 92) without structural chromosome aberrations was found in bone marrow cells of a patient with acute nonlymphocytic leukemia, FAB classification M1, following autologous bone marrow transplantation. This finding, which remained undetected during the remission phases and appeared at relapses, progressed to a hypotetraploid modal number (74 chromosomes) at the terminal phase of the disease. Together with two previous observations in patients with acute lymphoblastic leukemia with L2 morphology and a null cell immunotype, this observation supports the hypothesis that tetraploid karyotypes may represent unusual and aspecific patterns of clonal evolution.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume36
Issue number1
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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