Tetraploidy (92,XXYY) in an acute nonlymphocytic leukemia (M1) patient following autologous bone marrow transplantation

Leopoldo Zelante, Gianni Perla, Carlo Bodenizza, Mario M. Greco, Mario Carotenuto, Bruno Dallapiccola

Research output: Contribution to journalArticle

Abstract

Tetraploidy (4n = 92) without structural chromosome aberrations was found in bone marrow cells of a patient with acute nonlymphocytic leukemia, FAB classification M1, following autologous bone marrow transplantation. This finding, which remained undetected during the remission phases and appeared at relapses, progressed to a hypotetraploid modal number (74 chromosomes) at the terminal phase of the disease. Together with two previous observations in patients with acute lymphoblastic leukemia with L2 morphology and a null cell immunotype, this observation supports the hypothesis that tetraploid karyotypes may represent unusual and aspecific patterns of clonal evolution.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume36
Issue number1
DOIs
Publication statusPublished - 1988

Fingerprint

Tetraploidy
Autologous Transplantation
Bone Marrow Transplantation
Acute Myeloid Leukemia
Clonal Evolution
Null Lymphocytes
Karyotype
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chromosome Aberrations
Bone Marrow Cells
Chromosomes
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Tetraploidy (92,XXYY) in an acute nonlymphocytic leukemia (M1) patient following autologous bone marrow transplantation. / Zelante, Leopoldo; Perla, Gianni; Bodenizza, Carlo; Greco, Mario M.; Carotenuto, Mario; Dallapiccola, Bruno.

In: Cancer Genetics and Cytogenetics, Vol. 36, No. 1, 1988, p. 69-75.

Research output: Contribution to journalArticle

Zelante, Leopoldo ; Perla, Gianni ; Bodenizza, Carlo ; Greco, Mario M. ; Carotenuto, Mario ; Dallapiccola, Bruno. / Tetraploidy (92,XXYY) in an acute nonlymphocytic leukemia (M1) patient following autologous bone marrow transplantation. In: Cancer Genetics and Cytogenetics. 1988 ; Vol. 36, No. 1. pp. 69-75.
@article{a07911a1f633437fae6f3f7775225178,
title = "Tetraploidy (92,XXYY) in an acute nonlymphocytic leukemia (M1) patient following autologous bone marrow transplantation",
abstract = "Tetraploidy (4n = 92) without structural chromosome aberrations was found in bone marrow cells of a patient with acute nonlymphocytic leukemia, FAB classification M1, following autologous bone marrow transplantation. This finding, which remained undetected during the remission phases and appeared at relapses, progressed to a hypotetraploid modal number (74 chromosomes) at the terminal phase of the disease. Together with two previous observations in patients with acute lymphoblastic leukemia with L2 morphology and a null cell immunotype, this observation supports the hypothesis that tetraploid karyotypes may represent unusual and aspecific patterns of clonal evolution.",
author = "Leopoldo Zelante and Gianni Perla and Carlo Bodenizza and Greco, {Mario M.} and Mario Carotenuto and Bruno Dallapiccola",
year = "1988",
doi = "10.1016/0165-4608(88)90076-3",
language = "English",
volume = "36",
pages = "69--75",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Tetraploidy (92,XXYY) in an acute nonlymphocytic leukemia (M1) patient following autologous bone marrow transplantation

AU - Zelante, Leopoldo

AU - Perla, Gianni

AU - Bodenizza, Carlo

AU - Greco, Mario M.

AU - Carotenuto, Mario

AU - Dallapiccola, Bruno

PY - 1988

Y1 - 1988

N2 - Tetraploidy (4n = 92) without structural chromosome aberrations was found in bone marrow cells of a patient with acute nonlymphocytic leukemia, FAB classification M1, following autologous bone marrow transplantation. This finding, which remained undetected during the remission phases and appeared at relapses, progressed to a hypotetraploid modal number (74 chromosomes) at the terminal phase of the disease. Together with two previous observations in patients with acute lymphoblastic leukemia with L2 morphology and a null cell immunotype, this observation supports the hypothesis that tetraploid karyotypes may represent unusual and aspecific patterns of clonal evolution.

AB - Tetraploidy (4n = 92) without structural chromosome aberrations was found in bone marrow cells of a patient with acute nonlymphocytic leukemia, FAB classification M1, following autologous bone marrow transplantation. This finding, which remained undetected during the remission phases and appeared at relapses, progressed to a hypotetraploid modal number (74 chromosomes) at the terminal phase of the disease. Together with two previous observations in patients with acute lymphoblastic leukemia with L2 morphology and a null cell immunotype, this observation supports the hypothesis that tetraploid karyotypes may represent unusual and aspecific patterns of clonal evolution.

UR - http://www.scopus.com/inward/record.url?scp=0024255840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024255840&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(88)90076-3

DO - 10.1016/0165-4608(88)90076-3

M3 - Article

C2 - 3060252

AN - SCOPUS:0024255840

VL - 36

SP - 69

EP - 75

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -