TGFβ type II receptor signaling controls schwann cell death and proliferation in developing nerves

Maurizio D'Antonio, Anna Droggiti, M. Laura Feltri, Jürgen Roes, Lawrence Wrabetz, Rhona Mirsky, Kristján R. Jessen

Research output: Contribution to journalArticle

Abstract

During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo. Here, we tested whether the type II transforming growth factor (TGF) β receptor has a role in this process. We generated a conditional knock-out mouse in which the type II TGFβ receptor is specifically ablated only in Schwann cells. Inactivation of the receptor, evident at least from embryonic day 18, resulted in suppressed Schwann cell death in normally developing and injured nerves. Notably, the mutants also showed a strong reduction in Schwann cell proliferation. Consequently, Schwann cell numbers in wild-type and mutant nerves remained similar. Lack of TGFβ signaling did not appear to affect other processes in which TGFβ had been implicated previously, including myelination and response of adult nerves to injury. This is the first in vivo evidence for a growth factor receptor involved in promoting Schwann cell division during development and the first genetic evidence for a receptor that controls normal developmental Schwann cell death.

Original languageEnglish
Pages (from-to)8417-8427
Number of pages11
JournalJournal of Neuroscience
Volume26
Issue number33
DOIs
Publication statusPublished - Aug 16 2006

Keywords

  • CRE recombinase
  • Death
  • Neuregulin
  • Proliferation
  • Schwann cell
  • TGFβ

ASJC Scopus subject areas

  • Neuroscience(all)

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