TGF-β1 Overexpression in Murine Pancreas Induces Chronic Pancreatitis and Together with TNF-α, Triggers Insulin-Dependent Diabetes

F. Sanvito, A. Nichols, P. L. Herrera, J. Huarte, A. Wohlwend, J. D. Vassalli, L. Orci

Research output: Contribution to journalArticlepeer-review

Abstract

We have generated transgenic mice overexpressing TGF-β1 in pancreatic β cells. This resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by fibrotic and adipose tissues. A conspicuous disorganisation of the islets of Langerhans was also observed, however, the number of β cells was not decreased and the mice were normoglycemic. Backcrossing to transgenic mice overexpressing TNF-α in their islet β cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing β cells. (Part of this work has been reported in abstract form, Experientia 51, p. A9, February 1995).

Original languageEnglish
Pages (from-to)1279-1286
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume217
Issue number3
DOIs
Publication statusPublished - Dec 26 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

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