TGF-beta1 and IGF-1 expression are differently regulated by serum in metastatic and non-metastatic human breast cancer cells.

E. Perlino, S. Tommasi, L. Moro, A. Bellizzi, E. Marra, V. Casavola, S. J. Reshkin

Research output: Contribution to journalArticlepeer-review

Abstract

Transforming growth factor-beta (TGF-beta) exerts an inhibitory effect on epithelial cell proliferation while insulin-like growth factor-1 (IGF-1) is a positive regulator of proliferation and together they may participate in driving neoplastic progression. The regulation of TGF-beta1 and IGF-1 gene expression was analyzed in an in vitro model of an estrogen receptor positive (ER+), non-metastatic (MCF-7) and an (ER-), metastatic (MDA-MB-435) breast cancer cell line, respectively. Our results indicate a loss of the regulation of TGF-beta1 and the gain of the expression and upregulation of IGF-1 pathways during malignant progression. These data demonstrate that two factors, convergent on cell growth, can have divergent roles in the regulation of the expression of TGF-beta1.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalInternational Journal of Oncology
Volume16
Issue number1
Publication statusPublished - Jan 2000

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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