TGFbeta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas

Judith Müller, Birgit Samans, Jan Van Riggelen, Giovanni Fagà, K. N. Raquel Peh, Chia Lin Wei, Heiko Müller, Bruno Amati, Dean Felsher, Martin Eilers

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Deregulated expression of Myc under the control of an immunoglobulin enhancer induces lymphoma formation in mice. The development of lymphomas is limited by TGFβ-dependent senescence and high levels of Myc expression are continuously required to antagonize senescence. The biological processes underlying senescence are not fully resolved. We report here a comprehensive analysis of TGFβ-dependent alterations in gene expression when the Myc transgene is switched off. Our data show that Myc-induced target genes are down-regulated in a TGFβ-independent manner. In contrast, TGFβ is required to upregulate a broad spectrum of genes that are characteristic for different T-cell lineages when Myc is turned off. The analysis reveals a significant overlap between these Myc-repressed genes with genes that are targets of polycomb repressive complexes in embryonic stem cells. Therefore, TGFβ-dependent senescence is associated with gene expression patterns indicative of abortive cellular differentiation along several lineages.

Original languageEnglish
Pages (from-to)4622-4626
Number of pages5
JournalCell Cycle
Volume9
Issue number23
DOIs
Publication statusPublished - Dec 1 2010

Fingerprint

Transforming Growth Factor beta
Lymphoma
Gene Expression
Genes
Biological Phenomena
myc Genes
Cell Lineage
Embryonic Stem Cells
Transgenes
Immunoglobulins
Up-Regulation
T-Lymphocytes

Keywords

  • Lymphoma
  • Myc
  • Polycomb
  • Senescence
  • TGFβ

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology
  • Medicine(all)

Cite this

Müller, J., Samans, B., Van Riggelen, J., Fagà, G., Raquel Peh, K. N., Wei, C. L., ... Eilers, M. (2010). TGFbeta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas. Cell Cycle, 9(23), 4622-4626. https://doi.org/10.4161/cc.9.23.14211

TGFbeta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas. / Müller, Judith; Samans, Birgit; Van Riggelen, Jan; Fagà, Giovanni; Raquel Peh, K. N.; Wei, Chia Lin; Müller, Heiko; Amati, Bruno; Felsher, Dean; Eilers, Martin.

In: Cell Cycle, Vol. 9, No. 23, 01.12.2010, p. 4622-4626.

Research output: Contribution to journalArticle

Müller, J, Samans, B, Van Riggelen, J, Fagà, G, Raquel Peh, KN, Wei, CL, Müller, H, Amati, B, Felsher, D & Eilers, M 2010, 'TGFbeta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas', Cell Cycle, vol. 9, no. 23, pp. 4622-4626. https://doi.org/10.4161/cc.9.23.14211
Müller, Judith ; Samans, Birgit ; Van Riggelen, Jan ; Fagà, Giovanni ; Raquel Peh, K. N. ; Wei, Chia Lin ; Müller, Heiko ; Amati, Bruno ; Felsher, Dean ; Eilers, Martin. / TGFbeta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas. In: Cell Cycle. 2010 ; Vol. 9, No. 23. pp. 4622-4626.
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