TH-1 and TH-2 imbalance in patients with acute or stable multiple sclerosis

M. Saresella, P. Ferrante, D. Caputo, D. Trabattoni, M. L. Fusi, S. Ruzzante, M. Biasin, G. Aversa, M. Clenci

Research output: Contribution to journalArticlepeer-review

Abstract

Antigen-stimulated interleukin-2 production and mitogenstnnulated type 1 and type 2 cytokine production by peripheral blood mononuclear cells, as well as expression of Thl and Th2associated phenotypical markers, of B7-1. B7-2. and CD95 (Tas) on the surface of immune cells and serum concentration of soluble APO-l/Fas(sSPO-l/Fas) were evaluated in patients with either acute MS (AMS) or stable multiple sclerosis (SMS) and in healths controls (HC) Results showed a reduction of antigen-stimulated IL-2 production in MS patients compared 10 HC. the mitogen-stimulated type 1 cytokine production is increased and IL-10 production is reduced in MS patients compared to HC and in AMS compared to SMS: the production of the p40 IL-12 chain but not the production of the p7() homodimer. is increased in SMS compared to AMS and HC: CD4+, CD4+SLAJM+ and CD4+/CD7+ lymphocyte (Th1) are increased in MS compared to HC: B7-2 and Fas+ expressing monocyte are augmented in MS compared to HC and serum sAPO-1/Fas is augmented in AMS compared to SMS and HC In conclusion the immunological imbalance can be detected both functionally and phenotypically in MS disease confirming an immunological system impairment.

Original languageEnglish
Pages (from-to)30
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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