Antigen-stimulated interleukin-2 production and mitogenstnnulated type 1 and type 2 cytokine production by peripheral blood mononuclear cells, as well as expression of Thl and Th2associated phenotypical markers, of B7-1. B7-2. and CD95 (Tas) on the surface of immune cells and serum concentration of soluble APO-l/Fas(sSPO-l/Fas) were evaluated in patients with either acute MS (AMS) or stable multiple sclerosis (SMS) and in healths controls (HC) Results showed a reduction of antigen-stimulated IL-2 production in MS patients compared 10 HC. the mitogen-stimulated type 1 cytokine production is increased and IL-10 production is reduced in MS patients compared to HC and in AMS compared to SMS: the production of the p40 IL-12 chain but not the production of the p7() homodimer. is increased in SMS compared to AMS and HC: CD4+, CD4+SLAJM+ and CD4+/CD7+ lymphocyte (Th1) are increased in MS compared to HC: B7-2 and Fas+ expressing monocyte are augmented in MS compared to HC and serum sAPO-1/Fas is augmented in AMS compared to SMS and HC In conclusion the immunological imbalance can be detected both functionally and phenotypically in MS disease confirming an immunological system impairment.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology