Thalamic single-unit and local field potential activity in Tourette syndrome

Sara Marceglia; Domenico Servello; Guglielmo Foffani; Mauro Porta; Marco Sassi; Simona Mrakic-Sposta; Manuela Rosa; Sergio Barbieri; Alberto Priori

doi:10.1002/mds.22982

Thalamic single-unit and local field potential activity in Tourette syndrome

Sara Marceglia, Domenico Servello, Guglielmo Foffani, Mauro Porta, Marco Sassi, Simona Mrakic-Sposta, Manuela Rosa, Sergio Barbieri, Alberto Priori

Research output: Contribution to journal › Article › peer-review

Abstract

Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.

Original language	English
Pages (from-to)	300-308
Number of pages	9
Journal	Movement Disorders
Volume	25
Issue number	3
DOIs	https://doi.org/10.1002/mds.22982
Publication status	Published - Feb 15 2010

Keywords

Deep brain stimulation
Local field potentials
Thalamus
Tourette syndrome

ASJC Scopus subject areas

Clinical Neurology
Neurology

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title = "Thalamic single-unit and local field potential activity in Tourette syndrome",

abstract = "Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.",

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AU - Marceglia, Sara

AU - Servello, Domenico

AU - Foffani, Guglielmo

AU - Porta, Mauro

AU - Sassi, Marco

AU - Mrakic-Sposta, Simona

AU - Rosa, Manuela

AU - Barbieri, Sergio

AU - Priori, Alberto

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N2 - Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.

AB - Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.

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