Thalamic single-unit and local field potential activity in Tourette syndrome

Sara Marceglia, Domenico Servello, Guglielmo Foffani, Mauro Porta, Marco Sassi, Simona Mrakic-Sposta, Manuela Rosa, Sergio Barbieri, Alberto Priori

Research output: Contribution to journalArticle

Abstract

Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.

Original languageEnglish
Pages (from-to)300-308
Number of pages9
JournalMovement Disorders
Volume25
Issue number3
DOIs
Publication statusPublished - Feb 15 2010

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Tourette Syndrome
Deep Brain Stimulation
Tics
Thalamus
Ambulatory Surgical Procedures
Electrodes

Keywords

  • Deep brain stimulation
  • Local field potentials
  • Thalamus
  • Tourette syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Thalamic single-unit and local field potential activity in Tourette syndrome. / Marceglia, Sara; Servello, Domenico; Foffani, Guglielmo; Porta, Mauro; Sassi, Marco; Mrakic-Sposta, Simona; Rosa, Manuela; Barbieri, Sergio; Priori, Alberto.

In: Movement Disorders, Vol. 25, No. 3, 15.02.2010, p. 300-308.

Research output: Contribution to journalArticle

Marceglia, S, Servello, D, Foffani, G, Porta, M, Sassi, M, Mrakic-Sposta, S, Rosa, M, Barbieri, S & Priori, A 2010, 'Thalamic single-unit and local field potential activity in Tourette syndrome', Movement Disorders, vol. 25, no. 3, pp. 300-308. https://doi.org/10.1002/mds.22982
Marceglia, Sara ; Servello, Domenico ; Foffani, Guglielmo ; Porta, Mauro ; Sassi, Marco ; Mrakic-Sposta, Simona ; Rosa, Manuela ; Barbieri, Sergio ; Priori, Alberto. / Thalamic single-unit and local field potential activity in Tourette syndrome. In: Movement Disorders. 2010 ; Vol. 25, No. 3. pp. 300-308.
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