Abstract
Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 300-308 |
| Number of pages | 9 |
| Journal | Movement Disorders |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 15 2010 |
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Keywords
- Deep brain stimulation
- Local field potentials
- Thalamus
- Tourette syndrome
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Thalamic single-unit and local field potential activity in Tourette syndrome. / Marceglia, Sara; Servello, Domenico; Foffani, Guglielmo; Porta, Mauro; Sassi, Marco; Mrakic-Sposta, Simona; Rosa, Manuela; Barbieri, Sergio; Priori, Alberto.
In: Movement Disorders, Vol. 25, No. 3, 15.02.2010, p. 300-308.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thalamic single-unit and local field potential activity in Tourette syndrome
AU - Marceglia, Sara
AU - Servello, Domenico
AU - Foffani, Guglielmo
AU - Porta, Mauro
AU - Sassi, Marco
AU - Mrakic-Sposta, Simona
AU - Rosa, Manuela
AU - Barbieri, Sergio
AU - Priori, Alberto
PY - 2010/2/15
Y1 - 2010/2/15
N2 - Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.
AB - Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.
KW - Deep brain stimulation
KW - Local field potentials
KW - Thalamus
KW - Tourette syndrome
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UR - http://www.scopus.com/inward/citedby.url?scp=77649084596&partnerID=8YFLogxK
U2 - 10.1002/mds.22982
DO - 10.1002/mds.22982
M3 - Article
C2 - 20108375
AN - SCOPUS:77649084596
VL - 25
SP - 300
EP - 308
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 3
ER -