Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis

Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Chiara Lepre, Cherubino Di Lorenzo, Giorgio Di Lorenzo, Marco Scapeccia, Vincenzo Parisi, Mariano Serrao, Claudio Colonnese, Jean Schoenen, Francesco Pierelli

Research output: Contribution to journalArticle

Abstract

Background: Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Here we were aimed to verify functional connectivity between brain networks at rest and its relationship with thalamic microstructure in migraine without aura (MO) patients between attacks. Methods: Eighteen patients with untreated MO underwent 3 T MRI scans and were compared to a group of 19 healthy volunteers (HV). We used MRI to collect resting state data among two selected resting state networks, identified using group independent component (IC) analysis. Fractional anisotropy (FA) and mean diffusivity (MD) values of bilateral thalami were retrieved from a previous diffusion tensor imaging study on the same subjects and correlated with resting state ICs Z-scores. Results: In comparison to HV, in MO we found significant reduced functional connectivity between the default mode network and the visuo-spatial system. Both HV and migraine patients selected ICs Z-scores correlated negatively with FA values of the thalamus bilaterally. Conclusions: The present results are the first evidence supporting the hypothesis that an abnormal resting within networks connectivity associated with significant differences in baseline thalamic microstructure could contribute to interictal migraine pathophysiology.

Original languageEnglish
Article number100
JournalJournal of Headache and Pain
Volume17
Issue number1
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • Fractional anisotropy
  • Magnetic resonance imaging
  • Migraine
  • Resting state
  • Thalamus

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis'. Together they form a unique fingerprint.

  • Cite this