Thalamus volume and ambulation in multiple sclerosis: a cross-sectional study

Robert W. Motl, Robert Zivadinov, Niels Bergsland, Ralph H.B. Benedict

Research output: Contribution to journalArticlepeer-review


AIM: This cross-sectional study examined if subcortical gray matter (SGM) structures accounted for differences in timed 25-foot walk (T25FW) speed between multiple sclerosis (MS) patients and controls.

METHODS: Subjects underwent brain MRI and completed the T25FW. Volumes of the thalamus, caudate, putamen and pallidum were calculated from 3D T1-weighted structural brain images. T2 lesion volume (T2LV) was determined by using a semiautomated edge detection contouring-thresholding technique.

RESULTS: There were differences in T25FW speed, SGM volumes and T2LV between MS and controls. T25FW speed was associated with SGM volumes and T2LV in MS and controls. Thalamic volume partially accounted for the difference in T25FW speed between the MS and controls.

CONCLUSION: The reduction of thalamus volume is associated with compromised ambulation in MS patients.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalNeurodegenerative disease management
Issue number1
Publication statusPublished - 2016


  • imaging
  • MRI
  • multiple sclerosis
  • thalamus
  • walking

ASJC Scopus subject areas

  • Medicine(all)


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