Thalassemia and hypercoagulability

Ali T. Taher, Zaher K. Otrock, Imad Uthman, Maria D. Cappellini

Research output: Contribution to journalArticle

Abstract

Thalassemia is a congenital hemolytic disease caused by defective globin synthesis resulting in decreased quantity of globin chains. Although the life expectancy of β-thalassemia patients has markedly improved over the last few years, patients still suffer from many complications of this congenital disease. The presence of a high incidence of thromboembolic events, mainly in β-thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. In this paper, we review the molecular and cellular mechanisms leading to hypercoagulability in β-thalassemia, with a special focus on thalassemia intermedia being the group with the highest incidence of thrombotic events as compared to other types of thalassemias. We also discuss the recommendations for thrombosis prophylaxis in these patients.

Original languageEnglish
Pages (from-to)283-292
Number of pages10
JournalBlood Reviews
Volume22
Issue number5
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Thalassemia
Thrombophilia
Globins
beta-Thalassemia
Incidence
Life Expectancy
Thrombosis

Keywords

  • Hypercoagulable state
  • Thalassemia
  • Thrombosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Thalassemia and hypercoagulability. / Taher, Ali T.; Otrock, Zaher K.; Uthman, Imad; Cappellini, Maria D.

In: Blood Reviews, Vol. 22, No. 5, 09.2008, p. 283-292.

Research output: Contribution to journalArticle

Taher, AT, Otrock, ZK, Uthman, I & Cappellini, MD 2008, 'Thalassemia and hypercoagulability', Blood Reviews, vol. 22, no. 5, pp. 283-292. https://doi.org/10.1016/j.blre.2008.04.001
Taher, Ali T. ; Otrock, Zaher K. ; Uthman, Imad ; Cappellini, Maria D. / Thalassemia and hypercoagulability. In: Blood Reviews. 2008 ; Vol. 22, No. 5. pp. 283-292.
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