Thalassemia trait and arterial thromboembolic events: A systematic review and a meta-analysis of the literature

F. Dentali, E. Romualdi, W. Ageno, M. D. Cappellini, P. M. Mannucci

Research output: Contribution to journalArticle

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Abstract

Background: An increased risk of venous thromboembolic events has been reported in thalassemic patients, in particular in patients with thalassemia intermedia. The association between β-thalassemia trait and atherothrombotic cardiovascular events is not well established. Methods: In a systematic review and meta-analysis of the literature, we evaluated the association between β-thalassemia trait and arterial cardiovascular disease. Studies were identified from the MEDLINE and EMBASE (until July 2010) electronic databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a random-effects model. Statistical heterogeneity was evaluated with the I2 statistic. Results: Of the 354 identified articles, eight case-control studies were eligible for the analysis. β-Thalassemia trait was associated with a reduced risk of arterial cardiovascular disease (OR 0.45; 95% CI 0.45-0.60). Heterogeneity among studies was low (I2=13%). The protective effect of β-thalassemia trait was confined to male patients (OR 0.39; 95% CI 0.24-0.62), and was not observed in female subjects (OR 0.89; 95% CI 0.52-1.53). Conclusions: β-Thalassemia trait may act as a protective factor against the development of arterial cardiovascular and cerebrovascular disease in male subjects. Larger prospective studies are necessary to confirm these preliminary findings and to further investigate the mechanisms underlying this protective effect.

Original languageEnglish
Pages (from-to)917-921
Number of pages5
JournalJournal of Thrombosis and Haemostasis
Volume9
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Thalassemia
Meta-Analysis
Odds Ratio
Confidence Intervals
Cardiovascular Diseases
Cerebrovascular Disorders
beta-Thalassemia
MEDLINE
Case-Control Studies
Databases
Prospective Studies

Keywords

  • β-thalassemia trait
  • Arterial thrombosis
  • Cardiovascular disease

ASJC Scopus subject areas

  • Hematology

Cite this

Thalassemia trait and arterial thromboembolic events : A systematic review and a meta-analysis of the literature. / Dentali, F.; Romualdi, E.; Ageno, W.; Cappellini, M. D.; Mannucci, P. M.

In: Journal of Thrombosis and Haemostasis, Vol. 9, No. 5, 05.2011, p. 917-921.

Research output: Contribution to journalArticle

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