Thalidomide plus oral melphalan for advanced multiple myeloma: A phase II study

Massimo Offidani; Monica Marconi; Laura Corvatta; Attilio Olivieri; Massimo Catarini; Pietro Leoni

Thalidomide plus oral melphalan for advanced multiple myeloma: A phase II study

Massimo Offidani, Monica Marconi, Laura Corvatta, Attilio Olivieri, Massimo Catarini, Pietro Leoni

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Thalidomide exerts synergistic or additive effects when combined with other drugs. This study reports the toxicity and efficacy of the combination of thalidomide plus oral melphalan in 27 patients with advanced multiple myeloma. We found that this combination induces a high response rate and a long progression-free survival without significantly increasing thalidomide-related toxicity.

Original language	English
Pages (from-to)	1432-1433
Number of pages	2
Journal	Haematologica
Volume	88
Issue number	12
Publication status	Published - Dec 2003

Keywords

Melphalan
Multiple myeloma
Thalidomide

ASJC Scopus subject areas

Hematology

Cite this

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title = "Thalidomide plus oral melphalan for advanced multiple myeloma: A phase II study",

abstract = "Thalidomide exerts synergistic or additive effects when combined with other drugs. This study reports the toxicity and efficacy of the combination of thalidomide plus oral melphalan in 27 patients with advanced multiple myeloma. We found that this combination induces a high response rate and a long progression-free survival without significantly increasing thalidomide-related toxicity.",

keywords = "Melphalan, Multiple myeloma, Thalidomide",

author = "Massimo Offidani and Monica Marconi and Laura Corvatta and Attilio Olivieri and Massimo Catarini and Pietro Leoni",

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T1 - Thalidomide plus oral melphalan for advanced multiple myeloma

T2 - A phase II study

AU - Offidani, Massimo

AU - Marconi, Monica

AU - Corvatta, Laura

AU - Olivieri, Attilio

AU - Catarini, Massimo

AU - Leoni, Pietro

PY - 2003/12

Y1 - 2003/12

N2 - Thalidomide exerts synergistic or additive effects when combined with other drugs. This study reports the toxicity and efficacy of the combination of thalidomide plus oral melphalan in 27 patients with advanced multiple myeloma. We found that this combination induces a high response rate and a long progression-free survival without significantly increasing thalidomide-related toxicity.

AB - Thalidomide exerts synergistic or additive effects when combined with other drugs. This study reports the toxicity and efficacy of the combination of thalidomide plus oral melphalan in 27 patients with advanced multiple myeloma. We found that this combination induces a high response rate and a long progression-free survival without significantly increasing thalidomide-related toxicity.

KW - Melphalan

KW - Multiple myeloma

KW - Thalidomide

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ER -

Thalidomide plus oral melphalan for advanced multiple myeloma: A phase II study

Abstract

Keywords

ASJC Scopus subject areas

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