The β-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid

Alberto E. Panerai, Barbara Manfredi, Francesca Granucci, Paola Sacerdote

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

In this study we show that the opioid peptide β-endorphin exerts a tonic inhibitory effect on the proliferative response of splenocytes to the polyclonal mitogen phytohemoagglutinin throughout two separate sites of action: one central and one peripheral. The intracerebroventricular administration of β-endorphin, in fact, induces a significant inhibition of splenocyte proliferation. In contrast, both the intracerebroventricular and the peripheral administration of anti-β-endorphin γ globulins induce a significant increase in proliferation. Moreover, an increase of splenocyte proliferation was observed also after the intravenous administration of γ globulins and intraperitoneal naloxone, and this effect was still present in hypophysectomized rats. The data reported suggest that β-endorphin exerts a tonic inhibitory effect on proliferation, acting centrally, and peripherally throughout a paracrine/autocrine mechanism. FACS experiments show that the effect observed is not the consequence of an alteration of lymphocyte trafficking induced by the opioid.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalJournal of Neuroimmunology
Volume58
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Endorphins
Mitogens
Opioid Analgesics
Globulins
Opioid Peptides
Naloxone
Intravenous Administration
Lymphocytes

Keywords

  • Immunosuppression
  • Lymphocyte
  • Opioid
  • Proliferation
  • β-Endorphin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

The β-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid. / Panerai, Alberto E.; Manfredi, Barbara; Granucci, Francesca; Sacerdote, Paola.

In: Journal of Neuroimmunology, Vol. 58, No. 1, 1995, p. 71-76.

Research output: Contribution to journalArticle

Panerai, Alberto E. ; Manfredi, Barbara ; Granucci, Francesca ; Sacerdote, Paola. / The β-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid. In: Journal of Neuroimmunology. 1995 ; Vol. 58, No. 1. pp. 71-76.
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