Abstract
Experience with liver transplantation over a period of 11 years at the University of Pittsburgh is presented. The application of liver transplantation to cases of hepatocellular carcinoma has changed considerably over this 11‐year period with the sequential introduction of adjuvant and, more recently, neoadjuvant chemotherapy. Results with the combination of chemotherapy plus surgery appear to be better than results with either agent alone. Moreover, the early results with neoadjuvant therapy appear to be better than those achieved with adjuvant therapy. As a result of this experience, conceptual changes in the approach to the problem of hepatic cancer and the role of both chemotherapy and liver transplantation in its management have changed at the University of Pittsburgh. These changes are identified and discussed. © 1993 Wiley‐Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 78-82 |
| Number of pages | 5 |
| Journal | Journal of Surgical Oncology |
| Volume | 53 |
| Issue number | 3 S |
| DOIs | |
| Publication status | Published - 1993 |
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Keywords
- hepatic cancer
- surgery and chemotherapy for hepatic cancer
- total hepatectomy
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
The 11 ‐year pittsburgh experience with liver transplantation for hepatocellular carcinoma : 1981‐1991. / van Thiel, David H.; Carr, Brian; Iwatsuki, Shunzaburo; Selby, R. Richard; Fung, John J.; Starzl, Thomas E.
In: Journal of Surgical Oncology, Vol. 53, No. 3 S, 1993, p. 78-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The 11 ‐year pittsburgh experience with liver transplantation for hepatocellular carcinoma
T2 - 1981‐1991
AU - van Thiel, David H.
AU - Carr, Brian
AU - Iwatsuki, Shunzaburo
AU - Selby, R. Richard
AU - Fung, John J.
AU - Starzl, Thomas E.
PY - 1993
Y1 - 1993
N2 - Experience with liver transplantation over a period of 11 years at the University of Pittsburgh is presented. The application of liver transplantation to cases of hepatocellular carcinoma has changed considerably over this 11‐year period with the sequential introduction of adjuvant and, more recently, neoadjuvant chemotherapy. Results with the combination of chemotherapy plus surgery appear to be better than results with either agent alone. Moreover, the early results with neoadjuvant therapy appear to be better than those achieved with adjuvant therapy. As a result of this experience, conceptual changes in the approach to the problem of hepatic cancer and the role of both chemotherapy and liver transplantation in its management have changed at the University of Pittsburgh. These changes are identified and discussed. © 1993 Wiley‐Liss, Inc.
AB - Experience with liver transplantation over a period of 11 years at the University of Pittsburgh is presented. The application of liver transplantation to cases of hepatocellular carcinoma has changed considerably over this 11‐year period with the sequential introduction of adjuvant and, more recently, neoadjuvant chemotherapy. Results with the combination of chemotherapy plus surgery appear to be better than results with either agent alone. Moreover, the early results with neoadjuvant therapy appear to be better than those achieved with adjuvant therapy. As a result of this experience, conceptual changes in the approach to the problem of hepatic cancer and the role of both chemotherapy and liver transplantation in its management have changed at the University of Pittsburgh. These changes are identified and discussed. © 1993 Wiley‐Liss, Inc.
KW - hepatic cancer
KW - surgery and chemotherapy for hepatic cancer
KW - total hepatectomy
UR - http://www.scopus.com/inward/record.url?scp=84989642299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989642299&partnerID=8YFLogxK
U2 - 10.1002/jso.2930530522
DO - 10.1002/jso.2930530522
M3 - Article
AN - SCOPUS:84989642299
VL - 53
SP - 78
EP - 82
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 3 S
ER -