The 11 ‐year pittsburgh experience with liver transplantation for hepatocellular carcinoma: 1981‐1991

David H. van Thiel, Brian Carr, Shunzaburo Iwatsuki, R. Richard Selby, John J. Fung, Thomas E. Starzl

Research output: Contribution to journalArticle

Abstract

Experience with liver transplantation over a period of 11 years at the University of Pittsburgh is presented. The application of liver transplantation to cases of hepatocellular carcinoma has changed considerably over this 11‐year period with the sequential introduction of adjuvant and, more recently, neoadjuvant chemotherapy. Results with the combination of chemotherapy plus surgery appear to be better than results with either agent alone. Moreover, the early results with neoadjuvant therapy appear to be better than those achieved with adjuvant therapy. As a result of this experience, conceptual changes in the approach to the problem of hepatic cancer and the role of both chemotherapy and liver transplantation in its management have changed at the University of Pittsburgh. These changes are identified and discussed. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalJournal of Surgical Oncology
Volume53
Issue number3 S
DOIs
Publication statusPublished - 1993

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Liver Transplantation
Hepatocellular Carcinoma
Drug Therapy
Neoadjuvant Therapy
Liver Neoplasms
Combination Drug Therapy
Therapeutics

Keywords

  • hepatic cancer
  • surgery and chemotherapy for hepatic cancer
  • total hepatectomy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

The 11 ‐year pittsburgh experience with liver transplantation for hepatocellular carcinoma : 1981‐1991. / van Thiel, David H.; Carr, Brian; Iwatsuki, Shunzaburo; Selby, R. Richard; Fung, John J.; Starzl, Thomas E.

In: Journal of Surgical Oncology, Vol. 53, No. 3 S, 1993, p. 78-82.

Research output: Contribution to journalArticle

van Thiel, David H. ; Carr, Brian ; Iwatsuki, Shunzaburo ; Selby, R. Richard ; Fung, John J. ; Starzl, Thomas E. / The 11 ‐year pittsburgh experience with liver transplantation for hepatocellular carcinoma : 1981‐1991. In: Journal of Surgical Oncology. 1993 ; Vol. 53, No. 3 S. pp. 78-82.
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