The 2-oxopyrrolidinacetamide piracetam reduces infarct brain volume induced by permanent middle cerebral artery occlusion in male rats

A. Tortiglione, M. Minale, G. Pignataro, S. Amoroso, G. DiRenzo, L. Annunziato

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, the temporal development of focal cerebral infarction induced by permanent middle cerebral artery occlusion (pMCAO) and the effects of piracetam, a derivative of γ-aminobutyric acid widely used in clinical practice as a nootropic agent, on infarct area and volume were investigated. pMCAO caused a cerebral infarct whose size progressively increased after 3, 6, 9, and 24 h. Piracetam (125 mg/kg i.p.), administered 6, 9, and 22 h after pMCAO, did not reduce pMCAO-induced brain infarct area size detected at the 24th hour. By contrast, when this agent was administered at the doses of 250 and 500 mg/kg, it caused a marked reduction of the infarct area size. This reduction was observed in almost every brain slice affected by pMCAO, although statistical differences (p

Original languageEnglish
Pages (from-to)427-433
Number of pages7
JournalNeuropharmacology
Volume43
Issue number3
DOIs
Publication statusPublished - Sep 2002

Keywords

  • Infarct volume
  • Piracetam
  • pMCAO

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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