The 2004 Italian legislation on the application of assisted reproductive technology: Epilogue

Giovanni B. La Sala, Alessia Nicoli, Maria T. Villani, Illaria Rondini, Lucia Moscato, Isaac Blickstein

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate how the unique Italian fertility regulations (≤3 inseminated oocytes/cycle, transfer of all embryos, prohibition of embryo cryopreservation) affected outcomes of ART. Study design: Case-control study from the Center of Reproductive Medicine, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. We compared outcomes of ART patients between five years before (n = 1791) and five years after (n = 2474) the implementation of the law. Results: The mean embryo transfer (ET) rate was 3.1 ± 2.1 and 1.7 ± 1.1 before and after the law. Significantly more ICSI procedures were performed in women above 35 years old during the post-law period. The ET rate was higher before (88.6%) than after (80.5%) the law (OR 1.9, 95% CI 1.6, 2.2) especially in women >37 years undergoing ICSI (88.2 vs. 76.1%; OR 2.3, 95% CI 1.3, 4.2). The clinical pregnancy rates were practically unchanged but the proportion of triplet births significantly decreased after the law (10.3 vs. 4.1%, OR 2.7, 95% CI 1.4, 5.0). Conclusion: In contrast to interim analyses, we found that the statutory obligation to transfer all available embryos produced from up to three inseminated oocytes reduced the ET rates, especially in older women, and decreased the triplet births rate.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume161
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Embryo transfer rate
  • In vitro fertilization
  • Multiple pregnancy
  • Pregnancy rate
  • Regulations

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'The 2004 Italian legislation on the application of assisted reproductive technology: Epilogue'. Together they form a unique fingerprint.

  • Cite this