The 2005 Italian quality control study for the evaluation of CD4 cells in centers involved in the treatment of HIV type 1 patients

Federico Martini, Gianpiero D'Offizi, Enrico Girardi, Alessia Vitale, Eleonora Cimini, Bianca Mollicone, Crysoula Vlassi, Fernando Aiuti, L. Atripaldi, U. Bodini, D. De Francesco, G. De Soccio, L. Gallo, E. Gentileschi, M. G. Giudizi, C. Martini, M. Mordacchini, G. A. Moroni, P. P. Pagliaro, S. PirasL. Soldini, R. Vanacore, V. Vullo

Research output: Contribution to journalArticlepeer-review

Abstract

We report the results of an external quality control program, including 17 Italian centers involved in the care of patients infected by HIV, to evaluate CD4 T cell count proficiency and reproducibility. The centers received two commercial stabilized blood preparations, one with "normal" and one with "low" CD4 T cell content. The centers were asked to process the samples two times, 1 week apart, with the same procedure used for samples from HIV patients. Most centers showed a good performance of CD4 frequency and absolute count determinations. In particular, the "low" sample was correctly analyzed by all centers; only two underestimated the "normal" sample CD4 frequency, and only one underestimated the CD4 absolute count by >100 CD4 cells/μl. Overall, our data suggest that most Italian laboratories provide reliable and reproducible results in evaluating CD4 T cells in HIV+ samples.

Original languageEnglish
Pages (from-to)777-781
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 2007

ASJC Scopus subject areas

  • Immunology
  • Virology

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