The 2011-2012 pilot European Society of Cardiology Sentinel Registry of Transcatheter Aortic Valve Implantation: 12-month clinical outcomes

Martine Gilard, Michael Schlüter, Thomas M. Snow, Gianni Dall'Ara, Helene Eltchaninoff, Neil Moat, Javier Goicolea, Gian Paolo Ussia, Petr Kala, Peter Wenaweser, Marian Zembala, Georg Nickenig, Susanna Price, Eduardo Alegria Barrero, Bernard Iung, Pepe Zamorano, Gerhard Schuler, Roberto Corti, Ottavio Alfieri, Bernard PrendergastPeter Ludman, Stephan Windecker, Manel Sabate, Adam Witkowski, Haim Danenberg, Erwin Schroeder, Francesco Romeo, Carlos Macaya, Geneviève Derumeaux, Cécile Laroche, Michele Pighi, Roberta Serdoz, Carlo Di Mario

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Our aim was to assess one-year outcomes of patients enrolled in the pilot European Sentinel Registry of Transcatheter Aortic Valve Implantation (TAVI). Methods and results: One-year outcomes of 4,571 patients (81.4±7.2 years, 2,291 [50.1%] male) receiving TAVI with the SAPIEN XT (57.3%) or CoreValve prosthesis at 137 European centres were analysed using Kaplan-Meier and Cox proportional hazards regression techniques. At one year, 3,341 patients were alive, 821 had died, and 409 were lost to follow-up. Of 2,125 patients who underwent functional assessment, 1,916 (90%) were in New York Heart Association (NYHA) Class I/II at one year, with functional improvement from baseline noted in 1,682 patients (88%). One-year survival based on 4,564 patients was estimated at 79.1%. Independent baseline predictors of mortality were increasing age and logistic EuroSCORE, the presence of NYHA III/IV, chronic obstructive pulmonary disease, and atrial fibrillation. Female gender was associated with a 4% survival benefit at one year. Vascular access routes other than transfemoral were associated with poorer survival. Procedural failure and major periprocedural complications had an adverse impact on survival. Conclusions: Contemporary European experience attests to the effectiveness of routine TAVI in unselected elderly patients.

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalEuroIntervention
Volume12
Issue number1
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Aortic stenosis
  • Registry
  • Survival
  • Transcatheter aortic valve implantation (TAVI)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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