The 5 Ws of a gluten challenge for gluten-related disorders

Karla A. Bascuñán, Leda Roncoroni, Federica Branchi, Luisa Doneda, Alice Scricciolo, Francesca Ferretti, Magdalena Aray, Luca Elli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Gluten-related disorders (GRDs) are gradually emerging as epidemiologically relevant diseases, with a global prevalence estimated to be approximately 5% in the population. Conditions related to gluten ingestion include celiac disease (CD), wheat allergy (WA), and nonceliac gluten sensitivity (NCGS). Although mediated by different pathogenic pathways, these 3 conditions share similar clinical manifestations and can present a difficult differential diagnosis. The gluten challenge (GC) is an important diagnostic tool for GRDs, but there is great variability in regards to deciding which patients should be challenged, what amount of gluten should be used, what the GC duration should be, when and where the GC should occur, and, sometimes, why to conduct a GC. This review summarizes the current knowledge about the desirable characteristics of GCs in the 3 main GRDs following a 5 Ws approach-that is, the 5 main journalistic questions: who, what, when, where, why. The answers will help to determine the correct use of the GC in diagnosing GRDs.

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalNutrition Reviews
Volume76
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

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Glutens
Wheat Hypersensitivity
Celiac Disease
Differential Diagnosis
Eating

Keywords

  • Celiac disease
  • Gluten challenge
  • Gluten-related disorders
  • Nonceliac gluten sensitivity
  • Wheat allergy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Bascuñán, K. A., Roncoroni, L., Branchi, F., Doneda, L., Scricciolo, A., Ferretti, F., ... Elli, L. (2018). The 5 Ws of a gluten challenge for gluten-related disorders. Nutrition Reviews, 76(2), 79-87. https://doi.org/10.1093/nutrit/nux068

The 5 Ws of a gluten challenge for gluten-related disorders. / Bascuñán, Karla A.; Roncoroni, Leda; Branchi, Federica; Doneda, Luisa; Scricciolo, Alice; Ferretti, Francesca; Aray, Magdalena; Elli, Luca.

In: Nutrition Reviews, Vol. 76, No. 2, 01.01.2018, p. 79-87.

Research output: Contribution to journalArticle

Bascuñán, KA, Roncoroni, L, Branchi, F, Doneda, L, Scricciolo, A, Ferretti, F, Aray, M & Elli, L 2018, 'The 5 Ws of a gluten challenge for gluten-related disorders', Nutrition Reviews, vol. 76, no. 2, pp. 79-87. https://doi.org/10.1093/nutrit/nux068
Bascuñán KA, Roncoroni L, Branchi F, Doneda L, Scricciolo A, Ferretti F et al. The 5 Ws of a gluten challenge for gluten-related disorders. Nutrition Reviews. 2018 Jan 1;76(2):79-87. https://doi.org/10.1093/nutrit/nux068
Bascuñán, Karla A. ; Roncoroni, Leda ; Branchi, Federica ; Doneda, Luisa ; Scricciolo, Alice ; Ferretti, Francesca ; Aray, Magdalena ; Elli, Luca. / The 5 Ws of a gluten challenge for gluten-related disorders. In: Nutrition Reviews. 2018 ; Vol. 76, No. 2. pp. 79-87.
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