The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus

Salvatore De Cosmo, Sabrina Prudente, Olga Lamacchia, Daniela Lucchesi, Hetal Shah, Christine Mendonca, Laura Pucci, Luana Mercuri, Ernest V. Gervino, Thomas H. Hauser, Diego Bailetti, Giuseppe Penno, Mauro Cignarelli, Alessandro Doria, Vincenzo Trischitta

Research output: Contribution to journalArticle

Abstract

BackgroundWe investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM).MethodsFour samples, including a total of 3167 patients, were studied. The presence of low eGFR (2) was estimated from serum creatinine by means of the Modification of Diet in Renal Disease Study equation. Increased urinary albumin excretion was defined as an albumin-creatinine ratio (ACR) ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women.ResultsNo association was found between rs2383206 and low eGFR or increased ACR in each sample as well as in a pooled analysis (overall odds ratio = 1.07, 95% confidence interval 0.94-1.22, P = 0.31 and overall odds ratio = 1.00, 95% confidence interval 0.90-1.12, P = 0.95, respectively). No interaction was observed between rs2383206 and poor glycemic control [HbA1c was above the median in the pooled sample (7.7%) in modulating eGFR or ACR (P for interaction = 0.42 and 0.90, respectively)].ConclusionVariability at the 9p21 CAD locus is unlikely to play a role in modulating susceptibility to kidney dysfunction in patients with T2DM.

Original languageEnglish
Pages (from-to)4411-4413
Number of pages3
JournalNephrology Dialysis Transplantation
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • albuminuria
  • coronary artery disease
  • gene polymorphism
  • glomerular filtration rate

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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    De Cosmo, S., Prudente, S., Lamacchia, O., Lucchesi, D., Shah, H., Mendonca, C., Pucci, L., Mercuri, L., Gervino, E. V., Hauser, T. H., Bailetti, D., Penno, G., Cignarelli, M., Doria, A., & Trischitta, V. (2012). The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus. Nephrology Dialysis Transplantation, 27(12), 4411-4413. https://doi.org/10.1093/ndt/gfs148