The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome

Fatima Domenica Elisa De Palma, Valentina Del Monaco, Jonathan G. Pol, Margerie Kremer, Valeria D'Argenio, Gautier Stoll, Donatella Montanaro, Barbara Uszczyńska-Ratajczak, Cecilia C. Klein, Anna Vlasova, Gerardo Botti, Massimiliano D'Aiuto, Alfonso Baldi, Roderic Guigó, Guido Kroemer, Maria Chiara Maiuri, Francesco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

The molecular complexity of human breast cancer (BC) renders the clinical management of the disease challenging. Long non-coding RNAs (lncRNAs) are promising biomarkers for BC patient stratification, early detection, and disease monitoring. Here, we identified the involvement of the long intergenic non-coding RNA 01087 (LINC01087) in breast oncogenesis. LINC01087 appeared significantly downregulated in triple-negative BCs (TNBCs) and upregulated in the luminal BC subtypes in comparison to mammary samples from cancer-free women and matched normal cancer pairs. Interestingly, deregulation of LINC01087 allowed to accurately distinguish between luminal and TNBC specimens, independently of the clinicopathological parameters, and of the histological and TP53 or BRCA1/2 mutational status. Moreover, increased expression of LINC01087 predicted a better prognosis in luminal BCs, while TNBC tumors that harbored lower levels of LINC01087 were associated with reduced relapse-free survival. Furthermore, bioinformatics analyses were performed on TNBC and luminal BC samples and suggested that the putative tumor suppressor activity of LINC01087 may rely on interferences with pathways involved in cell survival, proliferation, adhesion, invasion, inflammation and drug sensitivity. Altogether, these data suggest that the assessment of LINC01087 deregulation could represent a novel, specific and promising biomarker not only for the diagnosis and prognosis of luminal BC subtypes and TNBCs, but also as a predictive biomarker of pharmacological interventions.

Original languageEnglish
Article number105249
JournalPharmacological Research
Volume161
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Biomarker
  • Breast cancer
  • LINC01087
  • Long non-coding RNA
  • Luminal breast cancer
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Pharmacology

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