The acceptance of in silico models for REACH: Requirements, barriers, and perspectives

Emilio Benfenati, Rodolfo G. Diaza, Antonio Cassano, Simon Pardoe, Giuseppina Gini, Claire Mays, Ralf Knauf, Ludger Benighaus

Research output: Contribution to journalArticle

Abstract

In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR) models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes.

Original languageEnglish
Article number58
JournalChemistry Central Journal
Volume5
Issue number1
DOIs
Publication statusPublished - Oct 7 2011

ASJC Scopus subject areas

  • Chemistry(all)

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    Benfenati, E., Diaza, R. G., Cassano, A., Pardoe, S., Gini, G., Mays, C., Knauf, R., & Benighaus, L. (2011). The acceptance of in silico models for REACH: Requirements, barriers, and perspectives. Chemistry Central Journal, 5(1), [58]. https://doi.org/10.1186/1752-153X-5-58