The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

Matteo Bellone, Arianna Calcinotto, Paola Filipazzi, Angelo De Milito, Stefano Fais, Licia Rivoltini

Research output: Contribution to journalArticle

Abstract

We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8+ T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor acidity, can revert T-cell anergy and increase the efficacy of immunotherapy.

Original languageEnglish
Article numbere22058
JournalOncoImmunology
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Active immunotherapy
  • Adoptive immunotherapy
  • Anergy
  • Melanoma
  • Prostate cancer
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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