The action of dopamine on rat caudate neurones intracellularly recorded

G. Bernardi, M. G. Marciani, C. Morocutti, F. Pavone, P. Stanzione

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The action of dopamine (DA) was studied on rat striatal neurones monosynaptically activated by the substantia nigra (SN) or the medial forebrain bundle (MFB) stimulation. DA, iontophoretically applied, slowly depolarized the membrane cell and decreased the firing rate. The membrane resistance was not modified during DA ejection. Short pulses (up to 300 msec) of DA had no effect on the neurone. These findings suggest that DA is not the fast excitatory transmitter of the nigro-striatum projection, but it plays a different role in this pathway.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalNeuroscience Letters
Volume8
Issue number3
DOIs
Publication statusPublished - 1978

Fingerprint

Dopamine
Neurons
Medial Forebrain Bundle
Corpus Striatum
Substantia Nigra
Cell Membrane
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bernardi, G., Marciani, M. G., Morocutti, C., Pavone, F., & Stanzione, P. (1978). The action of dopamine on rat caudate neurones intracellularly recorded. Neuroscience Letters, 8(3), 235-240. https://doi.org/10.1016/0304-3940(78)90128-3

The action of dopamine on rat caudate neurones intracellularly recorded. / Bernardi, G.; Marciani, M. G.; Morocutti, C.; Pavone, F.; Stanzione, P.

In: Neuroscience Letters, Vol. 8, No. 3, 1978, p. 235-240.

Research output: Contribution to journalArticle

Bernardi, G, Marciani, MG, Morocutti, C, Pavone, F & Stanzione, P 1978, 'The action of dopamine on rat caudate neurones intracellularly recorded', Neuroscience Letters, vol. 8, no. 3, pp. 235-240. https://doi.org/10.1016/0304-3940(78)90128-3
Bernardi, G. ; Marciani, M. G. ; Morocutti, C. ; Pavone, F. ; Stanzione, P. / The action of dopamine on rat caudate neurones intracellularly recorded. In: Neuroscience Letters. 1978 ; Vol. 8, No. 3. pp. 235-240.
@article{722c33dea6404b1ebfc2136461a1da02,
title = "The action of dopamine on rat caudate neurones intracellularly recorded",
abstract = "The action of dopamine (DA) was studied on rat striatal neurones monosynaptically activated by the substantia nigra (SN) or the medial forebrain bundle (MFB) stimulation. DA, iontophoretically applied, slowly depolarized the membrane cell and decreased the firing rate. The membrane resistance was not modified during DA ejection. Short pulses (up to 300 msec) of DA had no effect on the neurone. These findings suggest that DA is not the fast excitatory transmitter of the nigro-striatum projection, but it plays a different role in this pathway.",
author = "G. Bernardi and Marciani, {M. G.} and C. Morocutti and F. Pavone and P. Stanzione",
year = "1978",
doi = "10.1016/0304-3940(78)90128-3",
language = "English",
volume = "8",
pages = "235--240",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - The action of dopamine on rat caudate neurones intracellularly recorded

AU - Bernardi, G.

AU - Marciani, M. G.

AU - Morocutti, C.

AU - Pavone, F.

AU - Stanzione, P.

PY - 1978

Y1 - 1978

N2 - The action of dopamine (DA) was studied on rat striatal neurones monosynaptically activated by the substantia nigra (SN) or the medial forebrain bundle (MFB) stimulation. DA, iontophoretically applied, slowly depolarized the membrane cell and decreased the firing rate. The membrane resistance was not modified during DA ejection. Short pulses (up to 300 msec) of DA had no effect on the neurone. These findings suggest that DA is not the fast excitatory transmitter of the nigro-striatum projection, but it plays a different role in this pathway.

AB - The action of dopamine (DA) was studied on rat striatal neurones monosynaptically activated by the substantia nigra (SN) or the medial forebrain bundle (MFB) stimulation. DA, iontophoretically applied, slowly depolarized the membrane cell and decreased the firing rate. The membrane resistance was not modified during DA ejection. Short pulses (up to 300 msec) of DA had no effect on the neurone. These findings suggest that DA is not the fast excitatory transmitter of the nigro-striatum projection, but it plays a different role in this pathway.

UR - http://www.scopus.com/inward/record.url?scp=0018097422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018097422&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(78)90128-3

DO - 10.1016/0304-3940(78)90128-3

M3 - Article

C2 - 19605165

AN - SCOPUS:0018097422

VL - 8

SP - 235

EP - 240

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -