The action of glycine on rat epileptic foci

E. Cherubini, G. Bernardi, P. Stanzione, M. G. Marciani, N. Mercuri

Research output: Contribution to journalArticle

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Abstract

The action of glycine (Gly) intravenously injected on rat epileptic foci induced by strychnine or penicillin topically applied, was compared with that of GABA. Gly (450 mg/kg i.v.) produced a complete block of the spiking activity. The inhibitory action of GABA (80 mg/kg), in terms of threshold and duration, was stronger than the action of Gly. The same inhibitory effect was also observed if these amino acids were applied topically or intracisternally. These results are consistent with the possibility that Gly has a role in the rat cortical inhibition.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalNeuroscience Letters
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 1981

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Glycine
gamma-Aminobutyric Acid
Strychnine
Penicillins
Amino Acids

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cherubini, E., Bernardi, G., Stanzione, P., Marciani, M. G., & Mercuri, N. (1981). The action of glycine on rat epileptic foci. Neuroscience Letters, 21(1), 93-97. https://doi.org/10.1016/0304-3940(81)90064-1

The action of glycine on rat epileptic foci. / Cherubini, E.; Bernardi, G.; Stanzione, P.; Marciani, M. G.; Mercuri, N.

In: Neuroscience Letters, Vol. 21, No. 1, 01.01.1981, p. 93-97.

Research output: Contribution to journalArticle

Cherubini, E, Bernardi, G, Stanzione, P, Marciani, MG & Mercuri, N 1981, 'The action of glycine on rat epileptic foci', Neuroscience Letters, vol. 21, no. 1, pp. 93-97. https://doi.org/10.1016/0304-3940(81)90064-1
Cherubini E, Bernardi G, Stanzione P, Marciani MG, Mercuri N. The action of glycine on rat epileptic foci. Neuroscience Letters. 1981 Jan 1;21(1):93-97. https://doi.org/10.1016/0304-3940(81)90064-1
Cherubini, E. ; Bernardi, G. ; Stanzione, P. ; Marciani, M. G. ; Mercuri, N. / The action of glycine on rat epileptic foci. In: Neuroscience Letters. 1981 ; Vol. 21, No. 1. pp. 93-97.
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