L'ATTIVITA DELLA 17 BETA OH STEROIDO DEIDROGENASI E DELLA 5ALFA STEROIDO REDUTTASI NELLA CUTE DEL RATTO IPOFISECTOMIZZATO

Translated title of the contribution: The activity of 17 beta OH steroid dehydrogenase and 5 alpha steroid reductase in the skin of hypophysectomized rat

E. Rampini, C. Gambini, G. Moretti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Determinations were made in 12 rats (6 controls and 6 hypophysectomized). Skin was taken from the dorsal aspect (fur) and from the plantar (no fur) aspect and then incubated with testosterone labelled with C14 and with labelled 17 beta oestradiol. The products were analysed and quantified on the basis of the percentage of radioactivity recovered. The 17 beta OH steroid dehydrogenase is more active in the hypophysectomized rats than in the controls, in the dorsal skin, in the anagenetic and telogenetic phases of the hair follicle and in the plantar region. The activity of the 5 steroid reductase does not present greater variations than in the normals. This increase of the activity of the 17 beta OH in the skin after hypophysectomy, as similarly observed in the works of Wiest and Ridwell and Witorsch and Kitay, is a contribution to the role of the hypophysis in cutaneous steroidogenesis. (Magnin - Buenos Aires)

Translated title of the contributionThe activity of 17 beta OH steroid dehydrogenase and 5 alpha steroid reductase in the skin of hypophysectomized rat
Original languageItalian
Title of host publicationGiornale Italiano di Dermatologia / Minerva Dermatologica
Pages74-82
Number of pages9
Volume111
Edition2
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Dermatology

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