Abstract
The activities of tyrosine hydroxylase (TH), dihydropteridine reductase (DHPR), aromatic aminoacid decarboxylase (AAD) and glutamic acid decarboxylase (GAD), enzymes involved in the synthesis of neurotransmitters possibly implicated in epilepsy, were measured in some brain areas of rats with cobalt-induced epilepsy. Although TH, AAD and GAD were significantly decreased in the cortex of treated animals, the reduction was not correlated with the development of the electroclinical patterns of epilepsy. The reduction observed might be better explained by nerve degeneration caused by the experimental lesion.
| Original language | English |
|---|---|
| Pages (from-to) | 83-87 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1978 |
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ASJC Scopus subject areas
- Neuroscience(all)
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The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy. / Altamura, A. C.; Bonati, M.; Brunello, N.; Giordano, P. L.; Algeri, S.
In: Neuroscience Letters, Vol. 7, No. 1, 1978, p. 83-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy
AU - Altamura, A. C.
AU - Bonati, M.
AU - Brunello, N.
AU - Giordano, P. L.
AU - Algeri, S.
PY - 1978
Y1 - 1978
N2 - The activities of tyrosine hydroxylase (TH), dihydropteridine reductase (DHPR), aromatic aminoacid decarboxylase (AAD) and glutamic acid decarboxylase (GAD), enzymes involved in the synthesis of neurotransmitters possibly implicated in epilepsy, were measured in some brain areas of rats with cobalt-induced epilepsy. Although TH, AAD and GAD were significantly decreased in the cortex of treated animals, the reduction was not correlated with the development of the electroclinical patterns of epilepsy. The reduction observed might be better explained by nerve degeneration caused by the experimental lesion.
AB - The activities of tyrosine hydroxylase (TH), dihydropteridine reductase (DHPR), aromatic aminoacid decarboxylase (AAD) and glutamic acid decarboxylase (GAD), enzymes involved in the synthesis of neurotransmitters possibly implicated in epilepsy, were measured in some brain areas of rats with cobalt-induced epilepsy. Although TH, AAD and GAD were significantly decreased in the cortex of treated animals, the reduction was not correlated with the development of the electroclinical patterns of epilepsy. The reduction observed might be better explained by nerve degeneration caused by the experimental lesion.
UR - http://www.scopus.com/inward/record.url?scp=0017862158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017862158&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(78)90117-9
DO - 10.1016/0304-3940(78)90117-9
M3 - Article
C2 - 19605093
AN - SCOPUS:0017862158
VL - 7
SP - 83
EP - 87
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -