The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer

Valentina Tassinari; Valeriana Cesarini; Domenico Alessandro Silvestris; Angela Gallo

doi:10.1016/j.bbagrm.2018.12.007

The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer

Valentina Tassinari, Valeriana Cesarini, Domenico Alessandro Silvestris, Angela Gallo

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Review article › peer-review

Abstract

A-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

Original language	English
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
DOIs	https://doi.org/10.1016/j.bbagrm.2018.12.007
Publication status	Accepted/In press - Dec 31 2018

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title = "The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer",

abstract = "A-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.",

author = "Valentina Tassinari and Valeriana Cesarini and Silvestris, {Domenico Alessandro} and Angela Gallo",

year = "2018",

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doi = "10.1016/j.bbagrm.2018.12.007",

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T1 - The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer

AU - Tassinari, Valentina

AU - Cesarini, Valeriana

AU - Silvestris, Domenico Alessandro

AU - Gallo, Angela

PY - 2018/12/31

Y1 - 2018/12/31

N2 - A-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

AB - A-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

U2 - 10.1016/j.bbagrm.2018.12.007

DO - 10.1016/j.bbagrm.2018.12.007

M3 - Review article

C2 - 30605729

JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

SN - 1874-9399

ER -

The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer

Abstract

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