The ADAR1 editing enzyme is encapsidated into HIV-1 virions

Elisa Orecchini, Maurizio Federico, Margherita Doria, Claudia Arenaccio, Erica Giuliani, Silvia Anna Ciafrè, Alessandro Michienzi

Research output: Contribution to journalArticlepeer-review


Adenosine deaminase acting on RNA1 (ADAR1) was previously reported to affect HIV-1 replication. We report data showing that ADAR1 interacts with the HIV-1 p55 Gag protein, the major structural protein of the immature virus capsid. Furthermore, we found that the endogenous ADAR1 is incorporated into virions purified from the supernatant of primary HIV-1-infected CD4+ T lymphocytes. Additional experiments demonstrated that the expression of the p55 Gag protein is sufficient for ADAR1 incorporation into virus-like particles (VLPs).Overall, our data originally support the evidence that ADAR1 can be part of the cell protein array uploaded in HIV-1 particles.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
Publication statusPublished - Nov 1 2015


  • ADAR1
  • Encapsidation
  • HIV-1
  • P55 Gag

ASJC Scopus subject areas

  • Virology


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