Abstract
Adenosine deaminase acting on RNA1 (ADAR1) was previously reported to affect HIV-1 replication. We report data showing that ADAR1 interacts with the HIV-1 p55 Gag protein, the major structural protein of the immature virus capsid. Furthermore, we found that the endogenous ADAR1 is incorporated into virions purified from the supernatant of primary HIV-1-infected CD4+ T lymphocytes. Additional experiments demonstrated that the expression of the p55 Gag protein is sufficient for ADAR1 incorporation into virus-like particles (VLPs).Overall, our data originally support the evidence that ADAR1 can be part of the cell protein array uploaded in HIV-1 particles.
Original language | English |
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Pages (from-to) | 475-480 |
Number of pages | 6 |
Journal | Virology |
Volume | 485 |
DOIs | |
Publication status | Published - Nov 1 2015 |
Keywords
- ADAR1
- Encapsidation
- HIV-1
- P55 Gag
ASJC Scopus subject areas
- Virology