The added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study

Cristina Tassorelli, Rigmor Jensen, Marta Allena, Roberto De Icco, Zaza Katsarava, J Miguel Lainez, Jorge A Leston, Ricardo Fadic, Santiago Spadafora, Marco Pagani, Giuseppe Nappi, COMOESTAS Consortium

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Abstract

Background Medication-overuse headache (MOH) is a chronic disabling condition associated with a high rate of relapse. Methods We evaluated whether the adoption of electronic-assisted monitoring, advice and communication would improve the outcome over a follow-up of 6 months in a controlled, multicentre, multinational study conducted in six headache centres located in Europe and Latin America. A total of 663 MOH subjects were enrolled and divided into two groups: the Comoestas group was monitored with an electronic diary associated with an alert system and a facilitated communication option, and the Classic group with a paper headache diary. Results We observed a significantly higher percentage of overuse-free subjects in the Comoestas group compared with the Classic group: 73.1 vs 64.1% (odds ratio 1.45, 95% confidence interval 1.07-2.09, p = 0.046). The Comoestas group performed better also regarding the number of days/month with intake of acute drugs and the level of disability [Migraine Disability Assessment Score: Comoestas group - 42.5 ± 53.6 (35.5-49.3) and Classic group - 27.5 ± 56.1 (20.6-34.3) ( p < 0.003)]. Conclusion The adoption of the electronic tool improved the outcome of patients suffering from MOH after withdrawal from overused drugs. Information and communication technology represents a valid aid for optimizing the management of chronic conditions at risk of worsening or of relapsing. Trial registration The trial was registered at ClinicalTrials.gov (no. NCT02435056).

Original languageEnglish
Pages (from-to)1115-1125
Number of pages11
JournalCephalalgia
Volume37
Issue number12
DOIs
Publication statusPublished - Oct 2017

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Secondary Headache Disorders
Multicenter Studies
Communication
Headache
Latin America
Migraine Disorders
Pharmaceutical Preparations
Odds Ratio
Confidence Intervals
Technology
Recurrence

Keywords

  • Journal Article

Cite this

The added value of an electronic monitoring and alerting system in the management of medication-overuse headache : A controlled multicentre study. / Tassorelli, Cristina; Jensen, Rigmor; Allena, Marta; De Icco, Roberto; Katsarava, Zaza; Miguel Lainez, J; Leston, Jorge A; Fadic, Ricardo; Spadafora, Santiago; Pagani, Marco; Nappi, Giuseppe; COMOESTAS Consortium.

In: Cephalalgia, Vol. 37, No. 12, 10.2017, p. 1115-1125.

Research output: Contribution to journalArticle

Tassorelli, C, Jensen, R, Allena, M, De Icco, R, Katsarava, Z, Miguel Lainez, J, Leston, JA, Fadic, R, Spadafora, S, Pagani, M, Nappi, G & COMOESTAS Consortium 2017, 'The added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study', Cephalalgia, vol. 37, no. 12, pp. 1115-1125. https://doi.org/10.1177/0333102416660549
Tassorelli, Cristina ; Jensen, Rigmor ; Allena, Marta ; De Icco, Roberto ; Katsarava, Zaza ; Miguel Lainez, J ; Leston, Jorge A ; Fadic, Ricardo ; Spadafora, Santiago ; Pagani, Marco ; Nappi, Giuseppe ; COMOESTAS Consortium. / The added value of an electronic monitoring and alerting system in the management of medication-overuse headache : A controlled multicentre study. In: Cephalalgia. 2017 ; Vol. 37, No. 12. pp. 1115-1125.
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AU - De Icco, Roberto

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AU - Miguel Lainez, J

AU - Leston, Jorge A

AU - Fadic, Ricardo

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N2 - Background Medication-overuse headache (MOH) is a chronic disabling condition associated with a high rate of relapse. Methods We evaluated whether the adoption of electronic-assisted monitoring, advice and communication would improve the outcome over a follow-up of 6 months in a controlled, multicentre, multinational study conducted in six headache centres located in Europe and Latin America. A total of 663 MOH subjects were enrolled and divided into two groups: the Comoestas group was monitored with an electronic diary associated with an alert system and a facilitated communication option, and the Classic group with a paper headache diary. Results We observed a significantly higher percentage of overuse-free subjects in the Comoestas group compared with the Classic group: 73.1 vs 64.1% (odds ratio 1.45, 95% confidence interval 1.07-2.09, p = 0.046). The Comoestas group performed better also regarding the number of days/month with intake of acute drugs and the level of disability [Migraine Disability Assessment Score: Comoestas group - 42.5 ± 53.6 (35.5-49.3) and Classic group - 27.5 ± 56.1 (20.6-34.3) ( p < 0.003)]. Conclusion The adoption of the electronic tool improved the outcome of patients suffering from MOH after withdrawal from overused drugs. Information and communication technology represents a valid aid for optimizing the management of chronic conditions at risk of worsening or of relapsing. Trial registration The trial was registered at ClinicalTrials.gov (no. NCT02435056).

AB - Background Medication-overuse headache (MOH) is a chronic disabling condition associated with a high rate of relapse. Methods We evaluated whether the adoption of electronic-assisted monitoring, advice and communication would improve the outcome over a follow-up of 6 months in a controlled, multicentre, multinational study conducted in six headache centres located in Europe and Latin America. A total of 663 MOH subjects were enrolled and divided into two groups: the Comoestas group was monitored with an electronic diary associated with an alert system and a facilitated communication option, and the Classic group with a paper headache diary. Results We observed a significantly higher percentage of overuse-free subjects in the Comoestas group compared with the Classic group: 73.1 vs 64.1% (odds ratio 1.45, 95% confidence interval 1.07-2.09, p = 0.046). The Comoestas group performed better also regarding the number of days/month with intake of acute drugs and the level of disability [Migraine Disability Assessment Score: Comoestas group - 42.5 ± 53.6 (35.5-49.3) and Classic group - 27.5 ± 56.1 (20.6-34.3) ( p < 0.003)]. Conclusion The adoption of the electronic tool improved the outcome of patients suffering from MOH after withdrawal from overused drugs. Information and communication technology represents a valid aid for optimizing the management of chronic conditions at risk of worsening or of relapsing. Trial registration The trial was registered at ClinicalTrials.gov (no. NCT02435056).

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