The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease

Edoardo Savarino, Elisa Marabotto, Patrizia Zentilin, Marzio Frazzoni, Giorgio Sammito, Daria Bonfanti, Luca Sconfienza, Lorenzo Assandri, Lorenzo Gemignani, Alberto Malesci, Vincenzo Savarino

Research output: Contribution to journalArticle

Abstract

Introduction: Functional heartburn is defined by Rome III criteria as an endoscopy-negative condition with normal oesophageal acid exposure time, negative symptom association to acid reflux and unsatisfactory response to proton pump inhibitors. These criteria underestimated the role of non-acid reflux. Aim: To assess the contribution of impedance-pH with symptom association probability (SAP) analysis in identifying endoscopy-negative patients with reflux disease and separating them from functional heartburn. Methods: Consecutive endoscopy-negative patients treated with proton pump inhibitors (n=219) undergoing impedance-pH monitoring off-therapy were analysed. Distal acid exposure time, reflux episodes, SAP and symptomatic response to proton pump inhibitors were measured. Results: Based on impedance-pH/SAP, 67 (31%) patients were pH+/SAP+, 6 (2%) pH+/SAP-, 83 (38%) hypersensitive oesophagus and 63 (29%) functional heartburn. According to pH-metry alone/response to proton pump inhibitors, 62 (28%) were pH+/SAP+, 11 (5%) pH+/SAP-, 61 (28%) hypersensitive oesophagus and 85 (39%) functional heartburn. In the normal-acid exposure population the contribution of impedance-pH/SAP compared to pH-metry alone/response to proton pump inhibitors in identifying patients with reflux disease and functional heartburn resulted to be 10%. In patients with abnormal-acid exposure, the contribution of impedance-pH/SAP increased by 3%. Conclusion: Comparing impedance-pH testing with pH-metry alone plus the response to proton pump inhibitor therapy demonstrated that the latter ones cause underestimation of reflux disease patients and overestimation of functional heartburn patients.

Original languageEnglish
Pages (from-to)542-547
Number of pages6
JournalDigestive and Liver Disease
Volume43
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Impedance pH-metry
  • MII-pH
  • NERD
  • Non-acid reflux

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Savarino, E., Marabotto, E., Zentilin, P., Frazzoni, M., Sammito, G., Bonfanti, D., Sconfienza, L., Assandri, L., Gemignani, L., Malesci, A., & Savarino, V. (2011). The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease. Digestive and Liver Disease, 43(7), 542-547. https://doi.org/10.1016/j.dld.2011.01.016