The Addenbrooke’s Cognitive Examination Revised (ACE-R) and its sub-scores: normative values in an Italian population sample

Mattia Siciliano, Simona Raimo, Dario Tufano, Giuseppe Basile, Dario Grossi, Franco Santangelo, Luigi Trojano, Gabriella Santangelo

Research output: Contribution to journalArticle

Abstract

The Addenbrooke’s Cognitive Examination Revised (ACE-R) is a rapid screening battery, including five sub-scales to explore different cognitive domains: attention/orientation, memory, fluency, language and visuospatial. ACE-R is considered useful in discriminating cognitively normal subjects from patients with mild dementia. The aim of present study was to provide normative values for ACE-R total score and sub-scale scores in a large sample of Italian healthy subjects. Five hundred twenty-six Italian healthy subjects (282 women and 246 men) of different ages (age range 20–93 years) and educational level (from primary school to university) underwent ACE-R and Montreal Cognitive Assessment (MoCA). Multiple linear regression analysis revealed that age and education significantly influenced performance on ACE-R total score and sub-scale scores. A significant effect of gender was found only in sub-scale attention/orientation. From the derived linear equation, a correction grid for raw scores was built. Inferential cut-offs score were estimated using a non-parametric technique and equivalent scores (ES) were computed. Correlation analysis showed a good significant correlation between ACE-R adjusted scores with MoCA adjusted scores (r = 0.612, p 

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalNeurological Sciences
Volume37
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • ACE-R
  • Addenbrooke’s Cognitive Examination Revised
  • Mild cognitive impairment cognitive dysfunctions
  • Normative data
  • Normative values

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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    Siciliano, M., Raimo, S., Tufano, D., Basile, G., Grossi, D., Santangelo, F., Trojano, L., & Santangelo, G. (2016). The Addenbrooke’s Cognitive Examination Revised (ACE-R) and its sub-scores: normative values in an Italian population sample. Neurological Sciences, 37(3), 385-392. https://doi.org/10.1007/s10072-015-2410-z