Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 283-289 |
| Number of pages | 7 |
| Journal | Semin. Cancer Biol. |
| Volume | 59 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Adjuvant
- Immunotherapy
- Melanoma
- Neoadjuvant
- Targeted therapy
- alpha interferon
- bevacizumab
- dabrafenib
- ipilimumab
- nivolumab
- pembrolizumab
- trametinib
- vemurafenib
- adjuvant therapy
- cancer staging
- colitis
- disease classification
- distant metastasis free survival
- drug efficacy
- drug tolerability
- fatigue
- fever
- Guillain Barre syndrome
- high risk patient
- human
- lymph node dissection
- lymph node metastasis
- melanoma
- myocarditis
- nausea
- overall survival
- recurrence free survival
- Review
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The adjuvant treatment revolution for high-risk melanoma patients : Seminars in Cancer Biology. / Spagnolo, F.; Boutros, A.; Tanda, E. et al.
In: Semin. Cancer Biol., Vol. 59, 2019, p. 283-289.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The adjuvant treatment revolution for high-risk melanoma patients
T2 - Seminars in Cancer Biology
AU - Spagnolo, F.
AU - Boutros, A.
AU - Tanda, E.
AU - Queirolo, P.
N1 - Cited By :2 Export Date: 2 March 2020 CODEN: SECBE Correspondence Address: Queirolo, P.; Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCSItaly; email: paola.queirolo@hsanmartino.it Chemicals/CAS: bevacizumab, 216974-75-3, 1438851-35-4; dabrafenib, 1195765-45-7, 1195768-06-9; ipilimumab, 477202-00-9; nivolumab, 946414-94-4; pembrolizumab, 1374853-91-4; trametinib, 1187431-43-1, 871700-17-3; vemurafenib, 918504-65-1 References: Gershenwald, J.E., Scolyer, R.A., Hess, K.R., Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual: melanoma Staging: AJCC 8 th Edition (2017) CA Cancer J. Clin., 67 (6), pp. 472-492; Leiter, U., Stadler, R., Mauch, C., Survival of SLNB-positive melanoma patients with and without complete lymph node dissection: a multicenter, randomized DECOG trial (2015) J. Clin. 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PY - 2019
Y1 - 2019
N2 - The past 5 years have witnessed the results of many practice-changing studies that have dramatically improved the landscape of adjuvant therapy in patients with resected, high-risk melanoma. After a 20-year era of adjuvant interferon, the anti-CTLA-4 and anti-PD-1 immune-checkpoint inhibitors, and MAPK-directed targeted therapy brought a revolution into the adjuvant treatment of melanoma. These results came along with the practice-changing results of two large multicenter studies showing no benefit in terms of overall survival for completion lymph node dissection after positive sentinel node biopsy. In this review, we summarized the current state of the art of the adjuvant treatment of high-risk melanoma, with a view on future perspectives. © 2019
AB - The past 5 years have witnessed the results of many practice-changing studies that have dramatically improved the landscape of adjuvant therapy in patients with resected, high-risk melanoma. After a 20-year era of adjuvant interferon, the anti-CTLA-4 and anti-PD-1 immune-checkpoint inhibitors, and MAPK-directed targeted therapy brought a revolution into the adjuvant treatment of melanoma. These results came along with the practice-changing results of two large multicenter studies showing no benefit in terms of overall survival for completion lymph node dissection after positive sentinel node biopsy. In this review, we summarized the current state of the art of the adjuvant treatment of high-risk melanoma, with a view on future perspectives. © 2019
KW - Adjuvant
KW - Immunotherapy
KW - Melanoma
KW - Neoadjuvant
KW - Targeted therapy
KW - alpha interferon
KW - bevacizumab
KW - dabrafenib
KW - ipilimumab
KW - nivolumab
KW - pembrolizumab
KW - trametinib
KW - vemurafenib
KW - adjuvant therapy
KW - cancer staging
KW - colitis
KW - disease classification
KW - distant metastasis free survival
KW - drug efficacy
KW - drug tolerability
KW - fatigue
KW - fever
KW - Guillain Barre syndrome
KW - high risk patient
KW - human
KW - lymph node dissection
KW - lymph node metastasis
KW - melanoma
KW - myocarditis
KW - nausea
KW - overall survival
KW - recurrence free survival
KW - Review
U2 - 10.1016/j.semcancer.2019.08.024
DO - 10.1016/j.semcancer.2019.08.024
M3 - Article
VL - 59
SP - 283
EP - 289
JO - Semin. Cancer Biol.
JF - Semin. Cancer Biol.
SN - 1044-579X
ER -