The administration of a polyvalent mechanical bacterial lysate in elderly patients with COPD results in serological signs of an efficient immune response associated with a reduced number of acute episodes

Rossella Ricci, Candida Palmero, Gyada Bazurro, Anna Maria Riccio, Valentina Garelli, Eddi Di Marco, Carmelina Cirillo, Fulvio Braido, Giorgio Walter Canonica, Giovanni Melioli

Research output: Contribution to journalArticle


The administration of a polyvalent mechanical bacterial lysate (PMBL) in elderly patients with COPD has been shown to reduce the number of exacerbation. This is largely related to the involvement of cells belonging to the innate and the adaptive immune system (including dendritic cells, granulocytes, T and B lymphocytes and NK cells) that actively cooperate inducing the production of specific opsonizing antibodies directed to the antigens of PMBL. We have evaluated the production of antibodies directed to respiratory and systemic pathogens in a group of elderly COPD patients, recruited in a clinical trial, ancillary to a larger multicenter double blind, placebo-controlled, parallel-designed clinical trial in which patients were randomized to daily receive either PMBL or placebo. The treated group not only experienced a reduced number of seroconversion, but also, better controlled the number of infectious episodes and COPD exacerbations. It was thus evident that the administration of PMBL resulted not only effective in inducing the secretion of specific antibodies, but also effective in reducing the infectious episodes trough the potentiation of the antibody-mediated arm of the immune response.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalPulmonary Pharmacology and Therapeutics
Issue number1
Publication statusPublished - Feb 2014



  • Antibodies
  • Chronic obstructive pulmonary disease
  • Immune response
  • Polyvalent mechanical bacterial lysate
  • Respiratory tract infections

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)
  • Biochemistry, medical

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