The advantages of carbon fiber-based orthopedic devices in patients who have to undergo radiotherapy: An experimental evidence

Antonella Soriani, Lidia Strigari, Maria Grazia Petrongari, Vincenzo Anelli, Jacopo Baldi, Nicola Salducca, Roberto Biagini, Carmine Zoccali

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: The modern approach to primary and secondary muscular skeletal tumors is multidisciplinary. The right combination of chemotherapy, surgery and radiotherapy (RT) makes ob-taining local and distant disease more likely. When surgery is indicated, radiotherapy often has a fundamental role as an adjuvant treatment; however, the titanium alloy instrumentations interfere with Radiotherapy set-ting, decreasing its effectiveness. It is common opinion that carbon fiber-reinforced devices are convenient in case of adjuvant RT in muscular skeletal oncology. The aim of the study is to support this intuition with experimental data, verifying the more accurate estimation of the delivered dose during RT, comparing Carbon Fiber-Reinforced PEEK (CFRP) plates with titanium-alloy orthopedic devices in order to evaluate their effects on target volume identification and dose distribution for radiation treatment. Methods: Phantoms were then irradiated with a linear accelerator Varian 2100 C/D with photon beams of 6 and 15 MV energies. Ab-sorbed dose in the point of interest was verified by EBT3 gafchromic films above and below the two materials. Images from CT simulations were also analyzed in terms of Hounsfield numbers in patients with titanium and carbon fiber orthopedic implants in the spine or in the femur. Results: For a 6 MV photon beam, the doses measured just under the titanium-alloy plate were less than approximately 20% of the value calculated by the TPS. For a 15 MV beam energy, these differences were slightly lower. Using CFRP plate, the difference between measured and calculated doses was within ±3% for both energies, which was comparable with the statistical uncertainties. In the cases of simulated treatment of humerus titanium implants, the difference var-ies in range ± 10% with hot spot of + 10% and cold spot of-15%. Conclusions: The use of CFRP for orthopedic devices and implants provides a valuable advantage in identifying the target due to the reduction of artifacts. Clear imaging of the soft tissues surrounding the bone is useful and reduces the discrepancies between calcu-lated/delivered and measured doses, generating a more homogeneous dose distribution. Furthermore, there is a significant benefit in detecting the state of disease in CT imaging during the follow-up of treated patients. In-vivo studies are encouraged to verify whether a more effective radiotherapy leads to a decrease in local recurrence and local progression. (www.actabiomedica.com).

Original languageEnglish
Article numbere2020057
Pages (from-to)1-12
Number of pages12
JournalActa Biomedica
Volume91
Issue number3
DOIs
Publication statusPublished - Sep 11 2020

Keywords

  • Carbon fiber
  • Metastatic bone disease
  • Orthopaedic implant
  • Radiochromic film
  • Radiotherapy

ASJC Scopus subject areas

  • Medicine(all)

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