The Aeromonas metallo-β-lactamases: Genetics, enzymology, and contribution to drug resistance

Gian Maria Rossolini, Timothy Walsh, Gianfranco Amicosante

Research output: Contribution to journalArticle

Abstract

Aeromonads are environmental microorganisms that can be responsible for both human and animal infections. Individual Aeromonas strains can produce up to three different, inducible, chromosomally encoded β-lactamases, including a group I molecular class C cephalosporinase, a group 2d molecular class D penicillinase, and a group 3 molecular class B metallo-β-lactamase, which contribute to β-lactam resistance in members of this genus. Among these enzymes, the metallo-β-lactamases are clinically relevant because of their ability to hydrolyze carbapenem antibiotics, and also represent a relevant investigational model for studying molecular class B β-lactamases because of their unique enzymological behavior. An overview on the distribution, genetics, and enzymology of these enzymes is reported, and the contribution of these enzymes to microbial drug resistance is also discussed.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalMicrobial Drug Resistance
Volume2
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Microbiology (medical)
  • Pharmacology

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